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BELOTERO® REVIVE is a sterile, non-pyrogenic, viscoelastic, transparent injectable gel. It is made of cross-linked sodium hyaluronate, a natural substance found in the human body, used for treating photo-damaged skin and superficial fine lines through rehydration and smoothing. It is indicated for use in patients with early signs of skin aging, particularly those with dry or very dry skin.

Indications for Use of BELOTERO® REVIVE

BELOTERO® REVIVE is primarily indicated for treating the early signs of aging and photo-damaged skin. Its key applications include:

• Hydration: Rehydrates dry and very dry skin.
• Smoothing of Fine Lines: Targets and smoothens superficial fine lines.
• Facial Skin Treatment: Used to treat facial skin affected by dehydration, photo-damage, and the presence of fine lines.

It is not intended for use in areas like the glabellar lines (between the eyebrows) or nose.

Dosage and Administration of BELOTERO® REVIVE

Each syringe of BELOTERO® REVIVE contains 1 ml of hyaluronic acid gel with a concentration of 20 mg/ml. The gel is injected into the superficial to mid-dermis of the skin by a trained healthcare professional.

• Primary Ingredient: Cross-linked sodium hyaluronate (20 mg/ml).
• Injection Frequency: The expected results typically last up to 9 months, but this can vary depending on individual factors such as injection technique, treatment area, and the patient’s metabolism.
• Recommended Injection Volume: The dosage varies based on the area being treated and the patient’s needs, but 1 ml per session is common.

After the initial session, patients may require touch-up treatments based on their skin’s response and desired effect.

Side Effects and Precautions

As with all injectable treatments, there are potential side effects and precautions that patients should be aware of before undergoing treatment with BELOTERO® REVIVE.

• Common Side Effects:
  • Swelling, bruising, or redness at the injection site.
  • Tenderness, itching, or discomfort around the treated area.
  • Nodules or lumps may develop temporarily at the injection site.
• Serious but Rare Side Effects:
  • Vascular occlusion: If the product is injected into a blood vessel, it can lead to complications like blindness, stroke, or skin necrosis.
  • Allergic reactions: Hypersensitivity to any component, such as sodium hyaluronate or glycerol.

Contraindications include:

• Known hypersensitivity to any of the product’s components.
• Use in pregnant or breastfeeding women.
• Auto-immune diseases or general infections at the injection site.

Healthcare professionals should not inject BELOTERO® REVIVE into areas with inflammation, infection, or previously treated with permanent dermal fillers. Patients must be informed of potential risks before treatment and follow post-procedural care instructions.

Post-Treatment Care

Patients receiving BELOTERO® REVIVE injections should follow specific post-treatment guidelines to ensure the best results and minimize risks:

• Avoid Makeup: Patients should avoid applying makeup for at least 12 hours after treatment.
• Avoid Sun Exposure: Refrain from sunbathing, UV rays, and extreme temperatures (both heat and cold) for at least 2 weeks after the procedure.
• Physical Activity: Limit physical activity that involves facial expressions (e.g., smiling, talking, laughing) for at least one week.
• No Alcohol: Patients should avoid consuming alcohol 24 hours before and after the procedure to reduce bruising risks.

The healthcare provider will provide a detailed post-care plan to ensure the treated area heals properly and to avoid complications such as hematomas or infections.

Clinical Studies and Outcomes

Clinical studies have shown that BELOTERO® REVIVE is highly effective in treating photo-damaged skin and superficial fine lines, with improvements visible shortly after the injection. The product helps to rehydrate the skin, making it appear smoother and healthier.

• Duration of Effectiveness: The results typically last up to 9 months depending on the injection site, patient’s metabolism, and treatment volume.
• Patient Satisfaction: A majority of patients report smoother skin and a reduction in fine lines after treatment, with a high level of satisfaction due to the hydrating effect.

The product has also demonstrated an excellent safety profile, with few severe adverse events reported. However, healthcare professionals are advised to stop the injection immediately if patients show signs of vascular occlusion or unusual pain during the procedure.

Drug Interactions

There are several potential interactions between BELOTERO® REVIVE and other medications. Patients using anticoagulants, anti-platelet agents, or non-steroidal anti-inflammatory drugs (NSAIDs), like aspirin or ibuprofen, may have an increased risk of bruising or bleeding at the injection site. Additionally, patients with a history of herpes or other infections should be monitored closely, as the injection may trigger reactivation of the infection.

Patients should inform their healthcare provider of all medications and supplements they are currently taking before receiving BELOTERO® REVIVE.

Warnings and Precautions

Healthcare providers must exercise caution when injecting BELOTERO® REVIVE and avoid using the product in combination with other aesthetic procedures, such as peels, laser treatments, or dermabrasion before complete healing has occurred.

• Combined Treatments: BELOTERO® REVIVE can be used in combination with botulinum toxin or calcium hydroxylapatite (e.g., Radiesse®), but it must be injected into different areas of the face.
• Ethnic Skin Types: Patients with Fitzpatrick skin type V/VI or Asian skin types should be informed of the higher risk of tissue reactions, including swelling, itching, and erythema.