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Crespine Gel Plus is an orthopedic injectable filler that is used to reduce pain and swelling in the
joints for people who are suffering from osteoarthritis. The product contains non-animal based
hyaluronic acid, cross-linked hyaluronic acid, and prilocaine. The hyaluronic acids aid in
improving mobility in hips, knees, or other joints where the product is applied. The prilocaine is
used to reduce discomfort during injection. This gel is sterile, viscoelastic, resorbable, and
Crespine Gel Plus is manufactured by BioPolymer, which is a company that specializes in
creating medical devices.
Crespine Gel Plus are formulated to be injected between joints affected by osteoarthritis,
allowing it to form a protective layer of high-purity hyaluronic acid between worn out ends of
bones. This layer cushions and reduces friction in the joint, which then reduces pain and
swelling, while increasing mobility for the patient.
Crespine Gel Plus is an injectable filler that is implanted in between the patient’s joints. Proper
injection and placement of the gel is important for the efficacy of the product, so this product
must only be used and injected by trained and licensed medical professionals in conformity with
regional laws and by-laws.
Pain relief and improved mobility is usually experienced by the patients 5-7 days after the first
treatment. The duration of the effect can be affected by the age or level of activity of the patient,
but it generally lasts for 6 to 8 months before they can get a repeat injection to prolong the
Considering it is applied correctly by a trained medical professional, Crespine Gel Plus has
been proven safe and has minimal side effects. The active ingredient, hyaluronic acid, is
naturally occuring in the human body, so there will be few instances wherein a reaction occurs.
Most side effects are short-lived and are usually the result of the injection process itself, rather
than the product. Patients may experience the following after the injection:
● Warm sensation
● Pain and tenderness
● light-headedness or a sudden drop of blood pressure and heart rate
These symptoms should not be severe and should be gone within 5 days. Patients are
encouraged to monitor their injection site and report to their physician in case any other
reactions occur or if the symptoms worsen or persist.
Patients who are hypersensitive to any of the components in the gel should steer clear as this
may cause a hypersensitivity reaction any time between right after the injection to 4 weeks after.
Please also note that the safety of this implant has not been determined for
● Patients below 18 years of age
● Pregnant women
● Lactating women