FILLMED®

Inside the FILLMED® Laboratories Portfolio

FILLMED® Laboratories, formerly known as Laboratoires Filorga Medical, organizes its catalog around two injectable pillars. The first is ART FILLER®, a range of hyaluronic acid-based dermal fillers developed using Tri-Hyal® technology. It combines free HA with long- and very long-chain cross-linked HA to provide different levels of tissue support. The second is NCTF 135 and NCTF 135 HA, polyrevitalizing solutions designed for mesotherapy rather than volume addition.

The portfolio also includes NANOSOFT® for superficial intradermal delivery and Skin Perfusion, a professional skincare range used alongside selected aesthetic procedures.

The NCTF Heritage

NCTF® stands for New Cellular Treatment Factor, a formulation developed early in Laboratoires Filorga Medical’s history. The professional mesotherapy range includes NCTF® 135 and NCTF® 135 HA, which differ primarily in their hyaluronic acid concentrations. NCTF® 135 contains approximately 0.025 mg/mL HA, while NCTF® 135 HA contains 5 mg/mL. Both use non-cross-linked hyaluronic acid in a multi-ingredient revitalizing complex designed to improve skin quality.

Best FILLMED® Products Compared

Practitioners planning to buy FILLMED® online should first distinguish the ART FILLER® and NCTF® ranges by treatment objective. ART FILLER® provides targeted wrinkle correction and facial volume, while NCTF® formulations focus on skin quality. Their different compositions and intended applications should guide product selection.

All five ART FILLER® formulations contain 0.3% lidocaine to help reduce injection discomfort. Selection depends on the intended treatment area, gel characteristics, and manufacturer instructions.

Buy FILLMED® ART FILLER — Five Formulations for Different Treatment Goals

• ART FILLER® Universal is intended for medium-to-deep wrinkles, including nasolabial folds and marionette lines. An 18-month prospective, randomized, single-blind study evaluated its performance across several facial areas, including the lips, and reported sustained improvement in treated wrinkles [2]. Its applications make it a useful option when practitioners compare formulations for moderate facial correction, though product selection should depend on the individual treatment area and patient assessment.
• FILLMED® ART FILLER Volume is intended to restore facial volume and refine contours in areas such as the cheeks and chin. Its gel properties support deeper volumizing applications, while the included 0.3% lidocaine helps reduce injection discomfort. Practitioners should follow the recommended injection depth and technique.
• ART FILLER Lips is intended for lip augmentation, projection, and contour definition. Its formulation provides a more volumizing option than Lips Soft, with 0.3% lidocaine included to reduce injection discomfort. Practitioners should choose the administration technique based on the manufacturer’s instructions and the patient’s treatment goals.
• FILLMED® ART FILLER Lips Soft is designed for subtler lip enhancement, contour refinement, and selected perioral applications. Compared with Lips, its gel characteristics suit softer correction. Choose products based on the patient’s anatomy and desired degree of enhancement.
• ART FILLER Fine Lines is intended for superficial wrinkles, including crow’s feet and fine perioral lines. Its formulation is designed for shallower correction than the products used for deeper folds and facial volume. Administration should follow the product-specific instructions.

FILLMED® NCTF 135 HA and NanoSoft

Compared with HA-only skin boosters, FILLMED® NCTF® 135 HA combines 5 mg/mL non-cross-linked hyaluronic acid with 59 additional revitalizing ingredients, including vitamins, amino acids, minerals, coenzymes, and nucleosides [4]. The manufacturer’s published protocols describe an initial treatment series followed by maintenance, although session intervals vary between regional materials. Practitioners should follow the current instructions for use applicable to their product and jurisdiction. Documented treatment areas include the face, neck, and décolletage.

A randomized, controlled multicenter study involving 146 participants evaluated NCTF® 135 HA for superficial wrinkles and skin quality. The treatment group showed improvements in several measured outcomes, including skin hydration and radiance [1]. NCTF® 135 HA is available in 3 mL vials, with a five-vial presentation among its marketed options. Administration involves appropriate superficial intradermal injection techniques, including compatible use of NANOSOFT® where supported by the manufacturer’s instructions.

FILLMED® NANOSOFT® is a single-use device featuring three 0.6 mm silicone micro-cones designed for superficial intradermal injection. It is compatible with standard syringes and may be used with NCTF® 135 HA according to the applicable product and device instructions [5].

Full FILLMED® Product Range

FILLMED® offers several product families for professional aesthetic medicine. Clinics that order FILLMED® online should check that their chosen presentation is available and permitted in their market.

• ART FILLER®: Fine Lines, Universal, Volume, Lips, and Lips Soft, alongside ART FILLER® Eyes in markets where it is offered.
• NCTF®: NCTF® 135 and NCTF® 135 HA injectable formulations, plus NCTF® BOOST 135 HA for topical use.
• M-HA®: M-HA® 10 and M-HA® 18 formulations for skin-quality applications.
• NANOSOFT®: A single-use microneedle device for superficial intradermal delivery.
• Skin Perfusion: Professional skincare and complementary aesthetic treatment products, including peels and pre- and post-peel preparations.
• Collagen-induction products: JUVELOOK® and LENISNA®, PDLLA-based products included in FILLMED’s professional portfolio in selected markets.

Suppliers advertising FILLMED® for sale may carry only selected products from the manufacturer’s international range. Practitioners should therefore verify the formulation, pack size, intended use, and applicable regional requirements. Clinics that order FILLMED® wholesale should also consider expiry dates and storage conditions when planning inventory.

FILLMED® vs Other Professional Aesthetic Brands

Practitioners considering whether to purchase FILLMED® should compare its formulations, intended uses, and clinical evidence with those of competing brands.

FILLMED® and PROFHILO: Remodeling Versus Rebuilding

PROFHILO from IBSA is an injectable skin remodeller, not a filler and not a nutrient cocktail. A 2 mL syringe contains 64 mg of hyaluronic acid: 32 mg of high-molecular-weight HA and 32 mg of low-molecular-weight HA, stabilized by a thermal process rather than chemical cross-linking.

PROFHILO® is commonly administered using the Bio Aesthetic Points technique, with five injection points on each side of the face. A small 2025 single-arm study involving 20 participants evaluated a stabilized high- and low-molecular-weight HA hybrid complex administered through a similar injection pattern. The study reported improved skin firmness, but it did not directly compare PROFHILO® and FILLMED® [3].

NCTF® 135 HA takes a different approach, combining non-cross-linked HA with a multi-ingredient revitalizing complex. While both products address skin-quality concerns, their formulations and administration protocols differ. Neither should be treated as a direct substitute for ART FILLER® when the primary treatment objective is structural volume restoration.

FILLMED® and CYTOCARE®: Comparing Mesotherapy Formulations

CYTOCARE from Revitacare in France is the closest like-for-like rival to NCTF 135 HA. It combines non-cross-linked hyaluronic acid with a rejuvenating complex of vitamins, amino acids, minerals, and antioxidants. The range is graded mainly by HA content per 5 mL vial: CYTOCARE 502, 516, and 532 carry 2 mg, 16 mg, and 32 mg, respectively, and the 715 line sits higher still.

NCTF® 135 HA contains 60 ingredients, including 5 mg/mL non-cross-linked hyaluronic acid, vitamins, amino acids, coenzymes, and nucleosides [4]. Its formulation differs from the CYTOCARE® range in HA concentration and the composition of the accompanying complex. Practitioners should compare product-specific indications, administration requirements, and clinical evidence before selecting either treatment. NANOSOFT® may be used for superficial NCTF® delivery where supported by the applicable instructions.

FILLMED® and JALUPRO

JALUPRO combines selected amino acids, including glycine, proline, leucine, and lysine, with hyaluronic acid in formulations intended for skin revitalization. NCTF® 135 HA has a broader multi-ingredient composition, incorporating vitamins, minerals, coenzymes, and nucleosides alongside amino acids and HA. Although the ranges address overlapping skin-quality concerns, their formulations and administration protocols differ. Practitioners should evaluate the specific products rather than assuming equivalent clinical effects.

FILLMED® and FILORGA

FILORGA and FILLMED® share their origins in the aesthetic-medicine work of Dr. Michel Tordjman, who established the original laboratory in 1978. Their subsequent development separated the professional medical aesthetics business from the consumer skincare brand. FILLMED® continues to offer professional injectable products, including NCTF® 135 HA, while FILORGA® is primarily associated with consumer skincare.

FILLMED® and SESDERMA

SESDERMA is a Spanish skincare brand known for topical formulations using liposomal delivery technology, including products such as C-VIT and ACGLICOLIC. Its skincare range overlaps with Skin Perfusion in hydration, skin texture, and maintenance care. However, ART FILLER® and NCTF® are injectable treatments with different intended applications, so they should not be compared directly with topical cosmeceuticals.

FILLMED® and MESOESTETIC

MESOESTETIC offers professional aesthetic products, including chemical peels, skincare, and selected mesotherapy formulations. Its mesopeel range provides options for different skin concerns, while FILLMED® offers professional peel products alongside Skin Perfusion skincare. The brands overlap in topical treatment and skin-quality applications, but ART FILLER® represents a separate category of injectable volume-correcting products. Practitioners should compare individual products based on their intended use rather than treating the brands as directly interchangeable.

FILLMED® Side Effects, Contraindications and Regulatory Status

In the Fanian randomized NCTF 135 HA study, most adverse events were mild, injection-related, and resolved within 48 hours [1]. Typical short-term reactions to any intradermal or filler injection include redness, swelling, tenderness, and bruising at the injection site. With NanoSoft, the manufacturer reports that small papules form after injection and settle within about 24 hours [5].

Contraindications and Precautions

Hyaluronic acid fillers may cause nodules, delayed inflammatory reactions, and, rarely, serious vascular complications. Practitioners should assess anatomical risks, recognize signs of vascular compromise, and maintain appropriate emergency management protocols. Active infection or inflammation at the treatment site, relevant allergies, and other product-specific contraindications must also be considered. Restrictions involving chemical peels, dermabrasion, or previously implanted fillers should be checked against the current instructions for each product.

Because ART FILLER contains lidocaine, a known sensitivity to local anesthetics of the amide type matters when screening patients. Always follow the product-specific instructions for use.

Training matters as much as product choice. FILLMED® recommends in its IFU that injectors complete a technique program before using NCTF, and the same principle applies to every filler in the ART FILLER family. Record batch numbers, injection planes, and patient consent for every treatment.

CE Marking and FDA Status

ART FILLER® and NCTF® products are marketed as CE-marked medical devices in applicable European markets, while NANOSOFT® is a separately classified delivery device [5]. CE marking does not constitute US FDA approval. The ART FILLER® and NCTF® presentations discussed here should not be described as FDA-approved for US use. Practitioners should confirm current authorization and permitted indications in their jurisdiction before they purchase FILLMED® for clinical use.

Buy FILLMED® Wholesale From Medical Spa Rx

Medical Spa Rx serves licensed aesthetic practitioners comparing ART FILLER® and NCTF® presentations. Available products, pack sizes, and supporting documentation can be reviewed in its online catalogue.

Clinics that buy FILLMED® wholesale can contact the support team about quantities, pricing, and shipping arrangements.Licensed aesthetic practitioners looking to buy Fillmed products online can explore the ART FILLER and NCTF ranges available through Medical Spa Rx, with wholesale options for eligible professionals.

To order FILLMED® online, review the selected product details and complete any required account verification. Injectable treatments must be administered only by appropriately qualified professionals.

FAQs

Can PROFHILO® replace ART FILLER® when treating facial volume loss?

No. PROFHILO® is primarily used for skin-quality and remodeling applications, whereas ART FILLER® includes formulations intended for wrinkle correction and facial volume restoration. They have different product characteristics and intended uses, so treatment selection should depend on the patient’s concerns and the applicable product instructions.

What should practitioners compare when choosing between NCTF® 135 HA and CYTOCARE®?

Important factors include HA concentration, accompanying ingredients, product presentation, intended indications, and administration requirements. Both ranges contain HA-based formulations for skin-quality applications, but their compositions and supporting clinical evidence differ. Practitioners should evaluate the specific products rather than assume equivalent results.

Can NANOSOFT® be used with every FILLMED® injectable?

Do not assume any device is compatible with every injectable simply because it fits a standard syringe. NANOSOFT® is designed for superficial intradermal delivery and is associated with NCTF® treatment protocols. ART FILLER® products have their own administration requirements, which practitioners should follow according to the individual instructions for use.

How should practitioners compare NCTF® 135 and NCTF® 135 HA?

Both formulations contain a multi-ingredient revitalizing complex, but their hyaluronic acid concentrations differ. NCTF® 135 contains approximately 0.025 mg/mL HA, while NCTF® 135 HA contains 5 mg/mL. Treatment selection should also account for product-specific indications, instructions, and clinical assessment.

What should practitioners check before combining FILLMED® injectables with professional peels?

Check the instructions and precautions for both treatments, including recommended timing, skin condition, and any contraindications to combining procedures. A peel and an injectable should not automatically be scheduled together simply because both are offered within the FILLMED® portfolio. Product-specific guidance and clinical assessment should determine the treatment sequence.

What affects treatment-course costs when clinics order FILLMED® wholesale?

Total cost depends on the ART FILLER® syringes or NCTF® vials required, the planned number of sessions, delivery accessories, and ongoing maintenance needs. When evaluating FILLMED® at wholesale prices, clinics should also review pack sizes, expiry dates, shipping charges, and any applicable volume-pricing terms.

Are Skin Perfusion products interchangeable with FILLMED® injectables?

No. Skin Perfusion consists of topical skincare products intended for complementary aesthetic care. ART FILLER® and injectable NCTF® formulations have different administration routes and treatment objectives. Practitioners should use each product according to its instructions rather than treating topical and injectable products as substitutes.

The page and all of its displayed contents are for medical professionals, designed to inform only, and not as a replacement for medical advice.

Citations

[1] Fanian, Ferial et al. “A hyaluronic acid-based micro-filler improves superficial wrinkles and skin quality: a randomized prospective controlled multicenter study.” The Journal of dermatological treatment vol. 34,1 (2023): 2216323. doi:10.1080/09546634.2023.2216323

[2] David, Michel et al. “Long-Term Efficacy and Tolerability of a Medium G’ HA Filler with Tri-Hyal Technology on the Rejuvenation of the Mobile Facial Zone.” Clinical, cosmetic and investigational dermatology vol. 16 1795-1805. 13 Jul. 2023, doi:10.2147/CCID.S395353

[3] Yazdanparast, Taraneh et al. “Safety and Efficacy of a “High and Low Molecular Weight Hyaluronic Acid Hybrid Complex” Injection for Face Rejuvenation.” Journal of cosmetic dermatology vol. 24,4 (2025): e70117. doi:10.1111/jocd.70117

[4] FILLMED. “NCTF® 135 HA.” FILLMED, fillmed.com/revitalise-nctf/.

[5] NanoPass Technologies. “FILLMED and NanoPass Launch NANOSOFT™ Microneedles for Aesthetics.” PR Newswire, 3 Apr. 2019, www.prnewswire.com/il/news-releases/fillmed-and-nanopass-launch-nanosoft-tm-microneedles-for-aesthetics-855536718.html.

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Written and reviewed by the Medical Spa Rx Editorial Team 

All clinical and product claims on this page have been checked against peer-reviewed research, manufacturer data, and regulatory sources in accordance with our Editorial Policy .

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