Proper storage of knee injections is critical to maintaining their effectiveness. Whether it’s corticosteroids, hyaluronic acid, or other therapeutic agents, ensuring the right temperature and conditions is essential. Improper storage can compromise the potency of these treatments and impact patient outcomes.

Euflexxa, a highly purified hyaluronic acid, closely resembles the natural fluid found in joints. Approved for treating moderate knee osteoarthritis, Euflexxa provides relief from symptoms such as pain and stiffness. Unlike simple pain medications, a qualified healthcare professional administers Euflexxa directly into the knee.

In the following sections, we’ll explore Euflexxa injections and their benefits and determine the appropriate storage for this product.

Key Takeaways

  • Euflexxa is a unique treatment for knee osteoarthritis pain involving three injections. It is an alternative to avian-derived options.
  • Proper storage of Euflexxa at a temperature range of 2°C to 25°C (36°F to 77°F) and away from light is crucial to maintaining its effectiveness and safety.
  • Euflexxa should be used immediately after opening to prevent degradation and ensure patients receive the full therapeutic benefits.
  • Proper disposal of Euflexxa and its packaging is essential for safety and environmental reasons, following local regulations for medical waste disposal.

Understanding Euflexxa and Its Storage Requirements

Knee injections.

Euflexxa is a treatment for knee osteoarthritis pain, involving three injections for patients who haven’t found relief through simple analgesics or non-pharmacologic therapy.

Euflexxa stands out as the first non-avian-derived hyaluronic acid approved in the U.S., making it a unique alternative to avian-derived options. With properties mirroring healthy human synovial fluid and no chemical cross-linking, Euflexxa offers a minimized risk of related reactions, providing a safer option for managing osteoarthritis pain.

Euflexxa’s generic name is sodium hyaluronate. Proper storage at the right temperature and away from light is crucial to maintaining potency and safety. This treatment helps alleviate knee pain from osteoarthritis, but only if stored correctly.

Incorrect storage of Euflexxa can reduce its effectiveness or even make it harmful. Its quality depends heavily on being kept in ideal conditions, as it is made from sodium hyaluronate through bacterial fermentation. Strict handling recommendations—maintaining a specific temperature range before and after opening—are essential to ensure that patients receive the full benefit of their treatment without added risks.

Knee injections.

Proper storage of Euflexxa is crucial to maintain its effectiveness and safety. The manufacturer specifies that Euflexxa should be stored at a temperature range of 2°C to 25°C (36°F to 77°F).

  • Keeping the product within this range ensures that the sodium hyaluronate remains stable and retains its therapeutic properties.
  • Storing Euflexxa outside this temperature range can compromise its efficacy and potentially pose risks to patients.

In addition to temperature control, Euflexxa must be protected from light. Exposure to light can degrade the active ingredients, reducing the treatment’s effectiveness. It is recommended to keep Euflexxa in its original packaging until it is ready to be used, as the packaging is designed to shield the product from light exposure.

By adhering to these storage guidelines, healthcare providers can ensure that Euflexxa remains potent and safe for patients. Proper storage practices are essential for delivering the full therapeutic benefits of Euflexxa in managing knee osteoarthritis pain.

Handling Euflexxa Before and After Opening

Knee injections.
  • Shelf Life Before Opening: Euflexxa has a specific shelf life that must be adhered to in order to maintain its effectiveness. Before opening, it should be stored at a temperature range of 2°C to 25°C (36°F to 77°F) and protected from light. Under these conditions, the product typically remains stable until the expiration date printed on the packaging. 
  • Shelf Life After Opening: Once Euflexxa is opened, it should be used immediately to prevent contamination and ensure the integrity of the product. Any remaining solution in the syringe after the treatment should not be stored for future use. Using the product immediately after opening helps avoid any potential sodium hyaluronate degradation, ensuring that patients receive the full therapeutic benefits.

Disposal Instructions

Proper disposal of Euflexxa and its packaging is essential for safety and environmental reasons. Any unused product or remaining solution in the syringe should be disposed of in accordance with local regulations for medical waste.

This typically involves placing the used syringe and any remaining product in a sharps disposal container to prevent injury and contamination. The outer packaging can usually be disposed of with regular waste, but it is always best to check local guidelines to ensure compliance.

Following these handling instructions ensures that Euflexxa maintains its efficacy and safety and helps protect both patients and the environment.

Ensuring Optimal Treatment Outcomes for Patients

Proper storage of Euflexxa ensures its effectiveness in treating knee osteoarthritis. Storing Euflexxa within the recommended temperature range of 2°C to 25°C (36°F to 77°F) and protecting it from light preserves the stability and integrity of the sodium hyaluronate solution. These conditions help maintain the therapeutic properties of Euflexxa, ensuring that patients receive the full benefit of the treatment.

Adhering to these storage guidelines prevents the degradation of active ingredients, which is essential for achieving the desired clinical outcomes in pain relief and improved joint function.

Improper storage of Euflexxa can significantly impact its efficacy and pose risks to patient health. Exposure to temperatures outside the recommended range or light can cause the solution to degrade, reducing its ability to lubricate and cushion the knee joint effectively.

This degradation can lead to suboptimal treatment results, leaving patients with inadequate pain relief and continued joint discomfort. Moreover, compromised product integrity due to improper storage can increase the risk of adverse reactions, such as inflammation or infection, potentially exacerbating the patient’s condition.

Conclusion

Proper storage and handling of Euflexxa are crucial to maintaining its effectiveness and safety for patients with knee osteoarthritis. Adhering to the recommended storage conditions, including the temperature range of 2°C to 25°C and protection from light, is essential to ensure that the treatment remains potent.

Healthcare providers should also be mindful of the shelf life before and after opening the product and follow the appropriate disposal instructions to guarantee the integrity of Euflexxa. By following these guidelines, healthcare professionals can provide the maximum therapeutic benefits of Euflexxa to patients while prioritizing their safety and well-being.

FAQs

1. Does Euflexxa need to be refrigerated?

Yes, it’s crucial to store Euflexxa in a refrigerator. The temperature should be between 2°C and 25°C.

2. What happens if I don’t refrigerate Euflexxa?

If not stored properly, Euflexxa’s effectiveness may decrease. It could even spoil if left at room temperature for too long.

3. Can I use Euflexxa? That has been out of the fridge for a while.

No, you shouldn’t use it if it’s been unrefrigerated for an extended period. Always keep track of storage conditions and time out of the fridge.

4. Is there any particular way to handle Euflexxa when taking it from the refrigerator?

Handle with clean hands and avoid shaking or dropping the product; sudden movements can affect its composition.

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References

Ferring Pharmaceuticals. (n.d.). About EUFLEXXA. Retrieved from https://www.euflexxa.com/about-euflexxa/

Altman, R. D., Rosen, J. E., Bloch, D. A., Hatoum, H. T., & Korner, P. (2009, August). A double-blind, randomized, saline-controlled study of the efficacy and safety of EUFLEXXA® for treatment of painful osteoarthritis of the knee, with an open-label safety extension (The FLEXX Trial). In Seminars in arthritis and rheumatism (Vol. 39, No. 1, pp. 1-9). WB Saunders.

NPS MedicineWise. (n.d.). Consumer Medicine Information: EUFLEXXA. Retrieved from https://www.nps.org.au/assets/medicines/dc92b931-8ec5-4a66-a70f-a6b200972403.pdf