Facial wrinkles are a common concern as we age, often deepening due to the natural loss of collagen and elastin. Studies indicate that up to 90% of visible skin aging is caused by sun exposure, making it a leading factor in wrinkle development. Dermal fillers have become an increasingly popular solution to combat these signs of aging.

Neuramis Deep and Juvederm are two leading hyaluronic acid-based dermal fillers designed to restore volume and smooth out wrinkles. While both are effective, they differ in texture, longevity, and application, offering unique benefits depending on individual needs. Understanding these differences can help you make an informed choice.

This article will compare Neuramis Deep vs Juvederm, focusing on their effectiveness, safety, and overall results to guide you in selecting the best filler for your aesthetic goals.

Key Takeaways

  • Neuramis Deep and Juvederm are both hyaluronic acid-based dermal fillers designed to restore volume and smooth out wrinkles.
  • Neuramis Deep is effective for targeting moderate to deep wrinkles, such as nasolabial folds, lip augmentation, and facial contouring. Its cross-linked hyaluronic acid formula provides long-lasting results. 
  • Juvederm offers various formulations tailored to specific facial areas and aesthetic needs. Its smooth, gel-like consistency provides natural-looking results for lip augmentation, cheek enhancement, and smoothing nasolabial folds.
  • The formulation and composition of Neuramis Deep and Juvederm differ in terms of cross-linking technologies, consistency and texture, longevity and degradation, and lidocaine content, influencing their application and effectiveness for addressing deeper facial wrinkles and volume loss.

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Understanding Neuramis Deep and Juvederm

Facial treatment.

Neuramis Deep is a hyaluronic acid dermal filler designed to target moderate to deep wrinkles, such as nasolabial folds, and is also effective for lip augmentation and facial contouring. Its cross-linked hyaluronic acid formula helps restore volume and hydration to the skin, resulting in a smoother, more youthful appearance. 

Known for its high purity and durability, Neuramis Deep delivers long-lasting results, making it a popular choice for non-surgical aesthetic enhancements.

Juvederm, produced by Allergan, is a leading brand of hyaluronic acid-based fillers that address signs of aging like wrinkles, fine lines, and volume loss. Juvederm offers various formulations, each tailored to specific facial areas and aesthetic needs. Its smooth, gel-like consistency provides natural-looking results, making it ideal for lip augmentation, cheek enhancement, and smoothing nasolabial folds.

Juvederm effects can last from several months to over a year, depending on the formulation and treatment area.

Formulation and Composition

Facial treatment.

Neuramis Deep is formulated with cross-linked hyaluronic acid, which is derived using SHAPE technology. This advanced manufacturing process enhances the filler’s stability and resistance to degradation, resulting in longer-lasting effects. Neuramis Deep contains non-animal stabilized hyaluronic acid (NASHA), known for its biocompatibility and safety.

Similarly, Juvederm is also made with cross-linked hyaluronic acid but utilizes Hylacross and Vycross technologies, depending on the specific product. These technologies give Juvederm fillers a smooth, gel-like consistency that enhances their spreadability and integration into the skin. 

Key Differences in Composition

  • Cross-Linking Technologies: Neuramis Deep uses SHAPE technology, while Juvederm employs Hylacross and Vycross technologies. These variations affect the texture, longevity, and stability of the fillers. Juvederm’s Vycross technology, for instance, combines low and high molecular weight hyaluronic acid to enhance cross-linking efficiency, offering a smoother product that lasts longer.
  • Consistency and Texture: Neuramis Deep is known for its cohesive and firm structure, making it suitable for deeper wrinkles and facial contouring. In contrast, Juvederm’s smooth, gel-like consistency allows easy integration into the skin, providing natural and immediate results.
  • Longevity and Degradation: Both fillers are designed to be long-lasting. However, Juvederm’s Vycross formulations are often noted for slightly extended duration compared to standard cross-linked hyaluronic acid fillers like Neuramis Deep.
  • Lidocaine Content: Both Neuramis Deep and Juvederm include lidocaine for pain reduction during treatment, enhancing the patient experience.

Application for Deeper Facial Wrinkles and Volume Loss

Facial treatment.

Neuramis Deep is specifically designed to address deeper facial wrinkles and restore volume. The application techniques for Neuramis Deep typically include:

  • Linear Threading and Tunneling: This technique involves inserting the needle at an approximate angle of 30° parallel to the wrinkle or fold. The filler is injected into the mid-to-deep dermis while applying constant, low-to-moderate pressure on the plunger as the needle is slowly withdrawn.
  • Serial Puncture: Multiple small injections are made along the wrinkle or fold to ensure even distribution of the filler.
  • Fan Technique: The needle is inserted at a single entry point, and the filler is distributed in a fan-like pattern to cover a broader area.

For Juvederm fillers, these are the common application techniques:

  • Linear Threading: Similar to Neuramis, this technique involves injecting the filler along the length of the wrinkle or fold. The filler is placed in the mid-to-deep dermis to provide support and volume.
  • Cross-Hatching: This technique involves injecting the filler in a crisscross pattern to create a mesh-like structure that supports the skin and smooths out wrinkles.
  • Layering: Multiple layers of filler are injected to gradually build up volume, ensuring a smooth and natural appearance.
  • Micro-Droplet Technique: Small amounts of filler are injected at multiple points to achieve precise contouring and volume enhancement.

Duration of Effects and Patient Outcomes

Neuramis Deep is known for its long-lasting results, typically maintaining its effects for 9 to 12 months. The advanced SHAPE technology used in its formulation ensures that the hyaluronic acid is cross-linked effectively, providing stability and durability. Patients often require maintenance treatments every 4 to 6 months for optimal results.

In contrast, Juvederm fillers offer varying durations of effect depending on the specific product used. Generally, Juvederm fillers can last from 12 to 24 months. For example, Juvederm Voluma XC, which is used for cheek augmentation, can last up to two years. Regular touch-ups may be necessary to maintain the desired appearance.

Patient Satisfaction and Outcomes

Neuramis Deep and Juvederm have high patient satisfaction rates due to their effectiveness in reducing wrinkles and restoring facial volume. Patients report improved self-confidence and satisfaction with their appearance following treatment. The longevity of results and minimal downtime contribute to positive outcomes, making these fillers popular choices for non-surgical facial rejuvenation.

Selecting the Best Product for Specific Cosmetic Needs

When selecting between Neuramis Deep and Juvederm for cosmetic treatments, several factors should be considered:

  • Treatment Area: Due to its smooth, cohesive gel texture, Neuramis Deep is often preferred for deeper wrinkles and volume restoration in areas like the cheeks and nasolabial folds. Juvederm, with its range of products, offers tailored solutions for various facial areas, including lips, under-eye hollows, and fine lines.
  • Longevity: Juvederm products generally have a longer duration of effect, lasting up to 24 months for some formulations3. Neuramis Deep typically lasts 9 to 12 months, making it suitable for patients seeking shorter-term results.
  • Cost: Neuramis Deep is often more cost-effective than Juvederm, making it an attractive option for patients on a budget.
  • FDA Approval: Juvederm may be a more suitable choice for patients who prioritize FDA-approved products and seek longer-lasting effects since there is no Neuramis FDA approval yet.

Recommendations for Different Cosmetic Concerns

  • Deep Wrinkles and Volume Loss: For significant volume loss and deep wrinkles, Neuramis Deep is an excellent choice due to its robust formulation and cost-effectiveness. Juvederm Voluma XC is also highly recommended for cheek augmentation and deep wrinkle correction, offering long-lasting results.
  • Fine Lines and Surface Wrinkles: Juvederm Ultra and Juvederm Volbella are ideal for treating fine lines and surface wrinkles, providing a smooth and natural finish.
  • Lip Augmentation: Both Neuramis Deep and Juvederm offer effective solutions for lip augmentation. Neuramis Deep provides a natural-looking enhancement with a smooth texture, while Juvederm Volbella is specifically designed for subtle lip enhancement and smoothing perioral lines.
  • Under-Eye Hollows: Juvederm Volbella is particularly effective for treating under-eye hollows. Its soft and smooth consistency integrates well with the delicate skin in this area.

Conclusion

Neuramis Deep and Juvederm are both effective options for rejuvenating the face by using hyaluronic acid to hydrate and plump the skin. Neuramis stands out with its unique cross-linking technology, offering longer-lasting results, while Juvederm is known for its smooth consistency and natural integration under the skin. Both fillers have their strengths, catering to different aesthetic needs and treatment goals.

Choosing the right filler depends on your specific cosmetic concerns and desired longevity. Consulting with a professional can help you select the best option, ensuring you achieve and maintain a youthful appearance for months.

FAQs

1. What is the difference between Neuramis Deep and Juvederm?

Neuramis Deep and Juvederm are both hyaluronic acid-based dermal fillers. Neuramis Deep is known for its cost-effectiveness and shorter duration (9-12 months), while Juvederm offers a wider range of products with longer-lasting effects (up to 24 months) and FDA approval.

2. Are there any side effects of using Neuramis Deep or Juvederm?

Neuramis Deep and Juvederm can cause side effects such as redness, swelling, bruising, and tenderness at the injection site, but these are generally mild and temporary.

3. What is the SHAPE technology in Neuramis Deep fillers?

SHAPE technology in Neuramis Deep fillers involves a two-step cross-linking process that enhances the stability and longevity of the hyaluronic acid gel.

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References

Photoaging. Canadian Dermatology Association. Published February 5, 2024. https://dermatology.ca/public-patients/skin/photoaging/

Jung, J. M., Lee, W. S., Kim, H. T., Moon, Y. S., Paik, S. H., Lee, W. J., Chang, S. E., Lee, M. W., Won, C. H., & Kim, B. J. (2020). “A Multi-center, randomized, double blinded, comparative study of two hyaluronic acid fillers for temporary restoration of mid-face volume in Asians”. Journal of cosmetic dermatology, 19(7), 1619–1626. https://doi.org/10.1111/jocd.13218

My Ethos Spa. (n.d.). Cross-linked hyaluronic acid Korea dermal filler for face. Retrieved September 12, 2024, from https://myethosspa.com/cross-linked-hyaluronic-acid-korea-dermal-filler-for-face/