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JUVÉDERM® ULTRA 3 Indications for Use

JUVÉDERM® ULTRA 3 is an injectable hyaluronic acid-based dermal filler designed for mid and deep dermal injections to correct moderate to deep facial wrinkles and enhance lip volume and definition. The product is formulated with lidocaine to reduce discomfort during treatment.

Key Indications:

• Filling moderate to deep facial depressions
• Lip augmentation and contouring
• Mid and deep dermal injections for facial aesthetic corrections
• Lidocaine inclusion for pain reduction during procedures

JUVÉDERM® ULTRA 3 Dosage Information

JUVÉDERM® ULTRA 3 is packaged in a pre-filled, sterile, and disposable syringe containing 1 mL of product. Each box includes two syringes and 4 single-use 27G1/2” needles.

Composition:

• Hyaluronic Acid (HA): 24 mg/mL
• Lidocaine Hydrochloride: 3 mg/mL
• Phosphate Buffer (pH 7.2): q.s. 1 mL
• Volume per syringe: 1 mL

The cross-linked hyaluronic acid used is non-animal in origin, making it biocompatible and effective for long-lasting results.

JUVÉDERM® ULTRA 3 Side Effects and Precautions

Like all dermal fillers, JUVÉDERM® ULTRA 3 has potential side effects that patients should be made aware of before undergoing treatment. While most side effects are mild and temporary, it is essential to consider individual patient histories.

Common Side Effects:

• Inflammatory reactions: Redness, swelling, or tenderness at the injection site that may last up to a week.
• Bruising: Potential for hematoma formation, especially in patients on blood thinners.
• Induration or nodules: Small lumps may form at the injection site.
• Discoloration (Tyndall effect): Blueish tint may appear if the product is injected too superficially.
• Poor filling effect: In some cases, the filler may not provide the desired volume enhancement.

Serious Risks (though rare):

• Intravascular injection: Can lead to embolism, occlusion of vessels, ischemia, or infarction. Signs like blanching of the skin, unusual pain, or vision changes during or after injection require immediate medical attention.
• Necrosis and stroke: Tissue damage or more severe vascular complications, including temporary or permanent blindness, cerebral ischemia, and cerebral hemorrhage, have been reported.

Precautions:

• Avoid using JUVÉDERM® ULTRA 3 in the periorbital region (eyelids and crow’s feet) or glabellar area (forehead).
• Patients with a history of autoimmune diseases, severe allergies, or hypersensitivity to hyaluronic acid or lidocaine should undergo a skin hypersensitivity test.
• Patients on anticoagulants (e.g., warfarin, aspirin) or non-steroidal anti-inflammatory drugs (NSAIDs) should be advised about increased risks of bleeding and bruising.
• Pregnant and breastfeeding women, as well as children, should not undergo JUVÉDERM® ULTRA 3 injections.

JUVÉDERM® ULTRA 3 Clinical Studies or Real-World Outcomes

JUVÉDERM® ULTRA 3 has demonstrated high efficacy in both clinical trials and real-world use. The hyaluronic acid filler provides immediate visible results, with full effects settling in after a few days. In clinical evaluations, most patients report high satisfaction with the results, particularly in the treatment of nasolabial folds and lip augmentation.

Results Duration:

• Lasting effects for 9 to 12 months, depending on factors such as the injection technique, patient metabolism, and treatment area.

Patient Satisfaction:

• High patient satisfaction with the overall natural appearance of results.
• Minor touch-up treatments may be necessary to maintain optimal results over time.

JUVÉDERM® ULTRA 3 Drug Interactions

While JUVÉDERM® ULTRA 3 is generally safe, it is essential to be cautious about possible interactions, particularly due to the lidocaine component.

Important Considerations:

• Avoid using in patients taking medications that reduce hepatic metabolism, such as cimetidine or beta-blockers, as they can interfere with lidocaine metabolism.
• Care should be taken in patients with cardiac conduction disorders, as lidocaine can exacerbate these conditions.
• Ensure the patient is not using NSAIDs or other medications that can prolong bleeding time, as this increases the risk of bruising and hematoma formation.

JUVÉDERM® ULTRA 3 Aftercare Instructions

To minimize risks and optimize results, patients should follow specific post-injection guidelines after receiving JUVÉDERM® ULTRA 3.

Post-Treatment Care:

• Avoid touching or massaging the treated area for 6 hours post-injection to prevent infection.
• Patients should not apply makeup for 12 hours after treatment.
• Avoid extreme temperatures (hot baths, saunas) and direct sun exposure for two weeks following the procedure.
• Patients should avoid strenuous activity and alcohol for at least 24 hours to prevent exacerbation of swelling or bruising.

What to Expect:

• Redness and swelling may last up to a week, and bruising can occur but typically resolves within 7 to 10 days.
• Lidocaine ensures minimal discomfort during the procedure, but pain management post-treatment can be achieved using paracetamol (not NSAIDs).

Follow-Up Treatments

To maintain optimal results, patients may require follow-up treatments approximately every 9-12 months.

Touch-ups:

• For lip augmentation or facial contouring, touch-ups may be required within the first year to maintain the desired aesthetic.