Thread lift treatments have gained popularity in aesthetic medicine, with studies showing that Polydioxanone (PDO) threads can stimulate collagen production and improve skin texture. These threads are valued for their ability to tighten and rejuvenate the skin, making them a go-to option for non-surgical facelifts.

PDO threads are dissolvable sutures inserted beneath the skin to provide an instant lifting effect while encouraging long-term collagen growth. Over time, the threads break down naturally, leaving behind firmer, more youthful skin without requiring surgical intervention.

In this article, we will explore the dissolution process of PDO threads, how long they last, and what patients can expect in terms of results and aftercare.

Key Takeaways

  • PDO threads dissolve naturally through hydrolysis within six months, leaving no permanent residue behind.
  • The dissolution process stimulates collagen production, enhancing skin texture and firmness even after the threads have disappeared.
  • When performed correctly, complications from leftover material are rare, ensuring a safe and effective treatment.
  • Compared to PLLA and PCL threads, PDO threads break down faster, making them a temporary yet effective skin-tightening option.
  • Proper skincare and maintenance treatments help prolong the rejuvenating effects of a PDO thread lift.

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How PDO Threads Naturally Dissolve in the Body

PDO (Polydioxanone) threads are made from a biodegradable polymer that naturally dissolves within the body. Originally used in surgical sutures, these threads have a proven track record of safety and effectiveness in medical and aesthetic applications.

Once inserted, PDO threads gradually break down through hydrolysis, a process where the body’s fluids naturally degrade the material. During this time, they provide structural support, lifting sagging skin while stimulating collagen production for long-term rejuvenation.

As the threads dissolve, the body safely absorbs the byproducts without causing harm or inflammation. This temporary yet transformative process ensures that PDO threads enhance skin firmness and elasticity even after they disappear.

The PDO Threads Dissolution Process: Hydrolysis Explained

Many patients wonder, Are PDO threads dangerous? when considering the treatment, often unaware of how the body naturally processes them. The dissolution of PDO threads occurs through hydrolysis, a chemical reaction where water molecules gradually break down the polymer chains that form the threads. Over several months, they lose tensile strength, fragment, and are absorbed through the body’s natural metabolic processes.

As PDO threads break down, they convert into carbon dioxide and water, which are safely expelled through normal bodily functions. This controlled degradation process minimizes the risk of foreign body reactions, ensuring a smooth, predictable outcome.

Since PDO threads have been used in surgical sutures for decades, their safety and breakdown process are well-documented, making them a trusted option in aesthetic medicine.

Typical Resorption Timeline of PDO Threads

PDO threads generally dissolve within six months, though the exact timeline can vary based on several factors, including thread thickness, placement depth, and individual metabolism.

younger-looking skin
  • First Few Weeks: PDO threads provide an immediate lifting effect as they integrate into the tissue.
  • 1-3 Months: Hydrolysis begins, breaking down the material and stimulating collagen production.
  • 4-6 Months: Threads fully dissolve, leaving behind newly formed collagen that maintains skin firmness.
  • After 6 Months: The lifting effect gradually diminishes, but collagen stimulation helps maintain some benefits for up to a year.

While PDO threads dissolve relatively quickly, their effects can last longer due to the body’s natural collagen production.

Collagen Production and Skin Benefits After PDO Threads Dissolve

Even after PDO threads dissolve, they provide benefits by stimulating collagen synthesis. The mechanical stimulation from thread placement encourages fibroblasts to produce new collagen fibers, strengthening the skin’s structure and improving elasticity, texture, and volume.

  • Improved Skin Firmness: Collagen helps maintain a tighter, more youthful appearance.
  • Reduction in Fine Lines: Increased collagen fills in wrinkles, smoothing out the skin.
  • Enhanced Hydration and Elasticity: Collagen fibers retain moisture, keeping the skin plump and supple.
  • Prolonged Lifting Effect: Even after the threads dissolve, new collagen supports skin structure for months.

Do PDO Threads Leave Residue or Cause Permanent Changes?

One of the biggest concerns patients have about PDO threads is whether they leave permanent material behind. The good news is that PDO threads are designed to dissolve completely, leaving no residue or long-term buildup in the skin. As they break down, the body naturally absorbs and eliminates the byproducts without any lasting effects.

Unlike older thread lift techniques, modern PDO threads do not create scar tissue or permanent knots, making them a safer, more advanced option for skin tightening. While minor side effects like swelling or temporary irritation are possible, serious complications—such as visible thread remnants—are rare when the procedure is performed by a skilled practitioner.

In the rare event that a thread doesn’t dissolve properly, minor corrective treatments can address the issue. However, most patients can feel confident knowing that PDO thread lifts provide temporary enhancement without leaving behind foreign material or permanent alterations to their skin.

Comparing PDO Threads to PLLA and PCL Threads in Dissolution Time

PDO threads are not the only type used for thread lifts—PLLA (poly-L-lactic acid) and PCL (polycaprolactone) threads are also available. Each type has different dissolution rates and longevity. Key differences in thread dissolution time:

the thread
  • PLLA Threads: Take around 12-18 months to dissolve, offering longer-lasting results but requiring more integration time.
  • PCL Threads: Dissolve over 24-36 months, providing the longest-lasting effect but with slower collagen stimulation.

How to Maintain Long-Lasting Results After PDO Threads Treatment

Although PDO threads dissolve, proper aftercare and maintenance treatments can help extend their effects.

  • Follow Post-procedure Care: Avoid excessive facial movements, sleeping on the treated area, or applying heavy pressure for the first few weeks.
  • Use Collagen-boosting Skincare: Products containing peptides, retinol, or vitamin C support ongoing collagen production.
  • Stay Hydrated and Maintain a Healthy Diet: Hydration and a nutrient-rich diet promote skin elasticity and healing.
  • Combine with Other Treatments: Microneedling, RF therapy, and PRP injections enhance collagen stimulation and skin rejuvenation.
  • Schedule Maintenance Sessions: Repeat PDO thread treatments every 6-12 months to sustain results.

A consistent skincare routine and periodic aesthetic treatments can help maximize the benefits of PDO thread lifts.

Conclusion

PDO threads naturally dissolve within six months through hydrolysis, offering temporary structural support while stimulating collagen production for long-lasting skin rejuvenation. Compared to PLLA and PCL threads, PDO threads break down faster, making them an excellent choice for moderate lifting and subtle contouring.

Proper aftercare and complementary treatments—such as skin care maintenance and collagen-boosting therapies—can help maintain a youthful, refreshed appearance to prolong the benefits even after the threads dissolve.

FAQs

1. How long do PDO thread lift results last?

Results typically last 6-12 months, depending on individual factors such as age, skin type, and lifestyle.

2. Can I ask my doctor to remove my PDO threads if necessary?

Yes, your practitioner can remove your PDO threads if complications arise, but they usually dissolve naturally without intervention.

3. Are PDO thread lifts painful?

Patients may experience mild discomfort during the procedure, but numbing agents minimize pain. Some swelling and soreness may occur afterward.

4. Can I combine PDO threads with other treatments?

Practitioners may combine PDO thread lifts with fillers, Botox, microneedling, or laser treatments for enhanced skin rejuvenation.

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References

Samizadeh S, Samizadeh S. Polydioxanone (PDO) threads. In: Springer eBooks. ; 2024:199-209. doi:10.1007/978-3-031-47954-0_9

Research and Markets. Non-Surgical Skin Tightening Devices Industry Research 2024-2030: Use in Facial Rejuvenation Expands Addressable market for skin tightening Devices. GlobeNewswire News Room. https://www.globenewswire.com/news-release/2024/12/11/2995180/0/en/Non-Surgical-Skin-Tightening-Devices-Industry-Research-2024-2030-Use-in-Facial-Rejuvenation-Expands-Addressable-Market-for-Skin-Tightening-Devices.html. Published December 11, 2024.

Yetman D. What is a polydioxanone (PDO) thread lift? Healthline. Published February 18, 2021. https://www.healthline.com/health/beauty-skin-care/pdo-thread-lift