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INFORMATION

Product Description

LIPORASE® Indications for Use

LIPORASE® (Hyaluronidase) is primarily used to dissolve hyaluronic acid (HA) fillers in aesthetic procedures. It is an effective treatment for correcting overfilling, treating granulomas, and managing complications associated with HA injections. LIPORASE® can also be used for other therapeutic purposes, such as addressing fibrosis, resolving edema, and assisting in preparation for plastic surgery.

• Filler Dissolution: Corrects the volume of excess hyaluronic acid fillers in the dermis.
• Treatment of Granulomas: Effective in managing localized nodules that may occur after filler injections.
• Fibrous Cellulite and Edema: Helps in reducing fibrous cellulite and managing post-surgical or post-traumatic swelling.
• Post-Surgical Defect Correction: Useful in eliminating defects following lipolytic surgeries like double chin reduction or breast procedures.
• Necrosis Prevention: Prevents necrosis from occurring due to filler-related vascular compromise or skin saturation.
• Pigmentation Issues: Can treat blue spots caused by the “Tyndall effect” following filler injections.

LIPORASE®’s versatility makes it essential in both cosmetic and medical contexts, particularly for those undergoing dermal filler procedures or lipodissolving treatments.

LIPORASE® Dosage Information

The recommended dosage of LIPORASE® (Hyaluronidase) depends on the intended application, whether for dissolving hyaluronic acid fillers or enhancing the effect of lipodissolving injections. The product is typically mixed with saline and sometimes combined with lidocaine to reduce discomfort during treatment.

Filler Dissolution

• Dosage: Mix 3cc of saline with 1 vial of LIPORASE®. This mixture can dissolve 3cc of hyaluronic acid filler.
• Procedure: Inject the solution into the area where the filler needs to be dissolved. The dissolution process begins immediately, and the body absorbs the filler within a few hours.

Lipodissolving Injection

• Dosage: Mix 5cc of saline with 1 vial of LIPORASE®, which can be added to a 10cc lipodissolving V-line injection. For larger doses (e.g., 30cc), use 2 vials of LIPORASE®.
• Procedure: Inject the mixture into the targeted fat layer evenly, ensuring the hyaluronidase helps with the diffusion of the fat-dissolving agents.

LIPORASE®’s ease of use and customizable dosage make it adaptable for a variety of filler correction and fat reduction procedures.

LIPORASE® Side Effects and Precautions

While LIPORASE® (Hyaluronidase) is generally well-tolerated, there are some potential side effects and precautions that should be considered during its use. Most reactions are mild and temporary, but certain individuals may experience more serious complications.

Common Side Effects:

• Redness and swelling at the injection site, typically resolving within a few hours to a day.
• Bruising may occur at the injection area, but this is usually mild and transient.
• Discomfort or tenderness: Although lidocaine is often included to reduce pain, some patients may still feel minor discomfort post-injection.

Rare but Serious Side Effects:

• Allergic reactions: Rare but possible, particularly in patients with a known hypersensitivity to hyaluronidase.
• Infection: As with any injection, there is a small risk of infection if the procedure is not performed under sterile conditions.
• Overcorrection: Using too much LIPORASE® may lead to an overcorrection, where too much filler is dissolved, potentially requiring further aesthetic adjustments.

Precautions:

• Skin testing may be necessary for patients with a history of allergies to hyaluronidase or lidocaine.
• Avoid use in patients with compromised immune systems or open wounds to prevent infections or complications.
• Pregnant or breastfeeding women should consult with a physician before undergoing treatment with LIPORASE®.

Careful administration and patient assessment are crucial to minimizing the risk of complications with LIPORASE®.

LIPORASE® Clinical Studies and Real-World Outcomes

LIPORASE® (Hyaluronidase) has shown significant effectiveness in clinical settings for dissolving excess HA fillers and improving outcomes in aesthetic procedures. Its application is particularly noted for the immediate onset of filler dissolution, with patients reporting rapid improvements after treatment.

• Filler Dissolution: Patients typically notice a reduction in the volume of overfilled areas within a few hours after LIPORASE® treatment.
• Improvement of Aesthetic Results: When used correctly, LIPORASE® ensures that hyaluronic acid-based fillers are properly balanced, reducing the likelihood of granulomas, lumps, or other adverse outcomes.

In real-world outcomes, LIPORASE® is highly regarded for its fast action and efficiency in correcting aesthetic overcorrections or addressing filler-related complications. It is a staple in aesthetic medicine for practitioners needing to revise or fine-tune filler results.

LIPORASE® Drug Interactions

There are no significant drug interactions reported with LIPORASE® (Hyaluronidase). However, it is always advisable to review a patient’s medical history and current medications before proceeding with treatment to avoid potential complications.

Medications to Consider:

• Anticoagulants: Patients on blood thinners may experience increased bruising or bleeding at the injection site.
• Anti-inflammatory drugs: These medications can increase the risk of bruising or bleeding, although such side effects are usually mild.

As with any medical treatment, a full assessment of the patient’s health and current medications is essential to ensure the safest and most effective outcome.

LIPORASE® Performance and Benefits

LIPORASE® (Hyaluronidase) offers a range of performance benefits, making it an essential tool in aesthetic and cosmetic medicine. Its primary advantage lies in its ability to effectively and quickly dissolve hyaluronic acid fillers, providing a corrective solution for overfilling or adverse filler outcomes.

• Immediate Results: LIPORASE® begins dissolving HA fillers immediately, with visible results within hours.
• Versatility: Suitable for both filler corrections and enhancing the effects of lipodissolving injections.
• Pain Management: When combined with lidocaine, LIPORASE® ensures a more comfortable treatment process with minimal discomfort.
• Minimal Downtime: Patients can return to their normal activities shortly after treatment, with only mild swelling or bruising in most cases.

The quick action and predictable results of LIPORASE® make it a highly reliable product for aesthetic practitioners and patients alike.

LIPORASE® Storage and Handling

To maintain the integrity of LIPORASE® (Hyaluronidase), it should be stored at controlled room temperatures between 2-25°C. Proper storage ensures the product remains effective for filler correction and fat-dissolving procedures. The product should be mixed and administered immediately after reconstitution to prevent contamination.