The skin under the eyes is among the thinnest and most delicate on the body, making it particularly prone to aging signs like fine lines, wrinkles, and dark circles. As collagen production declines with age, this area often shows the earliest signs of aging, requiring targeted care to maintain a youthful appearance.

Polynucleotide treatment is gaining recognition as an effective, non-invasive solution for rejuvenating the under-eye area. By utilizing chains of nucleotides, it stimulates collagen production, enhances skin elasticity, and reduces the visibility of fine lines. The result is a natural, refreshed look that restores vitality to this sensitive area.

This article will explore how polynucleotides treatment addresses under-eye wrinkles, improves overall skin quality, and rejuvenates the delicate under-eye region.

Key Takeaways

  • Polynucleotides are natural DNA or RNA chains that rejuvenate the under-eye area by stimulating collagen production, enhancing elasticity, and reducing fine lines, wrinkles, and dark circles.
  • These treatments improve skin texture, boost hydration, and provide long-term rejuvenation with minimal invasiveness.
  • The treatment involves a consultation, precise injections with ultra-fine needles, and post-care instructions for optimal results.
  • Results begin to appear within 2–3 months and can last up to 6 months. Maintenance treatments every 6–12 months are recommended for sustained improvements.

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Understanding Polynucleotides and Their Benefits for Under-Eye Skin

Polynucleotides (PN) are natural chains of DNA or RNA that target the underlying causes of aging in the delicate under-eye area. By stimulating collagen production, they enhance skin elasticity, improve hydration, and reduce common concerns like fine lines, wrinkles, and dark circles. Unlike traditional fillers, polynucleotides promote cell regeneration, offering a natural, long-term solution for smoother, more youthful skin.

covering her right eye
  • Smooths Fine Lines and Wrinkles: Stimulates collagen to restore elasticity and reduce wrinkles, leaving the under-eye area refreshed.
  • Enhances Skin Texture: Reduces puffiness and dark circles while improving tone and texture.
  • Boosts Hydration: Locks in moisture, giving the under-eye area a plump, hydrated look.
  • Non-Invasive Option: A minimally invasive procedure without the need for surgery or fillers.
  • Sustainable Results: Improves skin quality over time, ensuring long-term rejuvenation.

Polynucleotides treatments provide a safe and natural way to restore the under-eye area. They offer lasting results that leave the skin looking youthful, radiant, and revitalized.

The Procedure

Using polynucleotides under eyes help stimulate collagen production to improve skin regeneration. The process of getting this treatment includes the following steps:

injection ready for dark circles
  • Consultation: During the initial session, the practitioner thoroughly evaluates the patient’s skin condition and discusses personalized treatment goals to achieve optimal results.
  • Preparation: The under-eye area is cleansed, and a topical numbing cream is applied for a pain-free experience.
  • Injection Technique: A specialized polynucleotide solution is administered using ultra-fine needles, reaching the deeper skin layers to boost collagen production and encourage skin renewal.

These treatments are generally safe, with mild side effects like swelling or redness that resolve quickly. However, individuals with fish allergies should consult their practitioner, as polynucleotides are often derived from salmon DNA. To ensure proper technique and minimize risks, a qualified professional should always perform the procedure in a sterile environment.

Expected Results and Number of Sessions

Polynucleotide treatments can significantly reduce the appearance of fine lines and wrinkles under the eyes. Most patients notice smoother, firmer skin with reduced dark circles. However, it’s important to set realistic expectations—while dramatic improvements are possible, results vary based on individual skin conditions and lifestyle factors.

Woman with rejuvenated under eyes.

Typically, optimal results are achieved with a series of 3 to 6 sessions, spaced 4 to 6 weeks apart. The exact number of treatments needed can vary depending on the severity of the under-eye concerns and the patient’s response to the treatment.

Factors Affecting Outcomes

  • Skin Condition: Your skin’s initial condition will influence how quickly you see results and how pronounced those results will be.
  • Age and Lifestyle: Age, overall health, and habits such as smoking or sun exposure can impact the effectiveness of the treatment.
  • Aftercare: Proper aftercare and follow-up treatments are crucial in maintaining and enhancing results.
  • Practitioner Skill: The expertise of the practitioner administering the treatment significantly affects the safety and efficacy of the procedure.

Aftercare and Maintenance for Long-Term Results

Proper aftercare is essential to maximize the benefits of polynucleotide treatments for under-eye rejuvenation and ensure long-term results. Patients should follow these post-treatment care instructions:

  • Avoid strenuous activities, alcohol, and extreme sun exposure for 24–48 hours after the procedure.
  • Use cold compresses to minimize swelling or bruising.
  • Stick to a gentle skincare routine, avoiding harsh exfoliants or active ingredients like retinoids for at least one week.

To maintain the results, patients should consider the following:

  • Apply a high-quality broad-spectrum SPF daily to protect the delicate under-eye area from UV damage.
  • Incorporate hydrating serums or moisturizers with ingredients like hyaluronic acid to support skin hydration.
  • Schedule maintenance treatments every 6–12 months to sustain collagen stimulation and skin regeneration.

Complementary treatments, such as microneedling or chemical peels, can enhance the effects of polynucleotides by further improving skin texture and tone. Additionally, patients can benefit from using skincare products enriched with antioxidants like vitamin C or peptides to promote skin health and boost collagen production.

Conclusion

Polynucleotide treatments offer a natural and effective solution for rejuvenating the delicate skin under your eyes. By reducing fine wrinkles, dark circles, and enhancing overall texture, these treatments help you achieve a refreshed, youthful appearance. Most patients notice visible improvements after a few sessions, with results that continue to enhance over time.

Polynucleotides can provide long-lasting benefits with proper hydration, collagen support, and consistent aftercare. This innovative approach provides a safe and reliable way to restore vitality and confidence to the under-eye area.

FAQs

1. What skin concerns can polynucleotide treatment address?

Polynucleotides effectively reduce fine lines, wrinkles, dark circles, and puffiness, improving the overall texture and tone of areas like the delicate skin under the eyes.

2. Is the procedure painful?

The procedure is minimally invasive. The practitioner administering the treatment may apply a numbing cream before treatment to ensure comfort. Most patients report little to no discomfort during the process.

3. How long does it take to see results?

Visible improvements typically begin 2-3 months after the first treatment. Depending on individual skin conditions, results continue to enhance over time and can last up to 6 months.

4. Are the results permanent?

No, the results are not permanent. Maintenance treatments help keep optimal and lasting effects of skin rejuvenation with polynucleotide injections.

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References

Farage MA, Miller KW, Elsner P, Maibach HI. Characteristics of the Aging Skin. Advances in Wound Care. 2013;2(1):5-10. doi:https://doi.org/10.1089/wound.2011.0356 

Alvin W, Chan L, Lee A, et al. Polynucleotides in Aesthetic Medicine: A Review of Current Practices and Perceived Effectiveness. International Journal of Molecular Sciences. 2024;25(15):8224-8224. doi:https://doi.org/10.3390/ijms25158224