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    AZZALURE®  distributors
    AZZALURE®  distributors
    AZZALURE®  distributors
    AZZALURE®  distributors

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    brand:

    AZZALURE®

    manufacturer:

    Galderma

    active substances:

    BOTULINUM TOXIN TYPE A

    strength:

    125 Speywood units

    pack size:

    1 X 125 Speywood units/ml Vial

    INFORMATION

    Azzalure® Indications for Use

    Azzalure® contains botulinum toxin type A, which is a neuromuscular blocker that temporarily relaxes facial muscles. The primary use of Azzalure is for adults under 65 to improve the appearance of glabellar lines (frown lines between the eyebrows) and lateral canthal lines (crow’s feet around the eyes). It works by preventing the release of acetylcholine, a chemical that triggers muscle contractions.

    • Target Areas: Moderate to severe glabellar lines and crow’s feet.
    • Mechanism of action: Blocks acetylcholine at nerve-muscle junctions, resulting in temporary muscle relaxation.

    Azzalure® Dosage Information

    Azzalure is administered as an injection by trained physicians and should only be used for a single treatment session.

    • Unit: 125 Speywood units per vial.
    • Treatment frequency: Injections should not be given more frequently than once every 12 weeks.
    • Procedure: Your physician will reconstitute the powder with a solution before injecting it into the target muscles.
    • Effect onset: Results typically become noticeable within a few days of the injection.

    Azzalure® Side Effects and Precautions

    As with any botulinum toxin-based product, there are risks associated with Azzalure injections, although not everyone experiences them. Most side effects are temporary and mild to moderate in severity.

    • Very common side effects (affecting more than 1 in 10 users):
      • Redness, swelling, bruising, itching, or discomfort at the injection site.
      • Headache.
    • Common side effects (affecting 1 to 10 in 100 users):
      • Drooping eyelid.
      • Swelling of the eyelid.
      • Temporary facial paralysis.
      • Eye-related issues such as dry eye, watery eyes, twitching, or dim vision.
    • Uncommon side effects (affecting 1 to 10 in 1,000 users):
      • Blurred or double vision, dizziness.
      • Allergic reactions, including itchy rash.
    • Rare side effects (affecting 1 to 10 in 10,000 users):
      • Eye movement disorder, more severe allergic reactions like swelling of the face or difficulty breathing.

    Azzalure® Precautions:

    • Avoid treatment if you have a known allergy to botulinum toxin or an infection at the injection site.
    • Patients with neuromuscular disorders, dysphagia (swallowing issues), or bleeding disorders should discuss their condition with their doctor before treatment.
    • There is a risk of muscle weakness spreading beyond the injection site in rare cases.

    Clinical Studies or Real-World Outcomes

    Azzalure has been extensively studied for its effectiveness in treating glabellar lines and crow’s feet. In clinical trials, patients reported visible reductions in facial lines within 3 to 4 days of treatment, with peak results typically seen around 14 days post-injection.

    • Efficacy: Clinical trials demonstrated significant improvement in glabellar lines in over 80% of treated patients after the first week of treatment. Crow’s feet lines also showed a marked reduction in severity.
    • Duration of effect: The cosmetic benefits of Azzalure last for approximately 3 to 4 months, after which muscle activity gradually returns, and repeat treatments may be necessary.

    Azzalure® Drug Interactions

    Certain medications and other botulinum toxin injections can interact with Azzalure, potentially increasing its effects or side effects.

    • Medications to avoid:
      • Aminoglycoside antibiotics (e.g., gentamicin, amikacin).
      • Muscle relaxants or drugs that interfere with neuromuscular transmission.
    • Other considerations:
      • Inform your physician of any recent botulinum toxin injections, as using different products in combination may increase the risk of unwanted effects.

    Special Considerations

    • Pregnancy and breastfeeding: Azzalure should not be used during pregnancy or while breastfeeding. There is insufficient evidence to establish safety in these cases.
    • Driving and machinery: Temporary blurred vision or muscle weakness following treatment may impair your ability to drive or operate machinery.

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