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PLINEST is a sterile, injectable dermal biorevitalization product based on PN-HPT™ (Polynucleotides Highly Purified Technology), designed to restore skin quality, hydrate, and stimulate cellular regeneration. Manufactured by Mastelli Srl in Italy, PLINEST represents one of the most clinically validated skin-repair formulations using high-purity DNA polymers, specifically tailored to improve texture, elasticity, and tone of the skin.

Each 2ml syringe contains 40mg of long-chain polynucleotides—naturally derived DNA fractions that stimulate fibroblasts, promote collagen synthesis, and trigger deep tissue regeneration. PLINEST is widely used in anti-aging treatments, acne scar remodeling, and skin priming for procedures like lasers, fillers, and microneedling.

PLINEST Key Features and Benefits

PLINEST offers a comprehensive approach to aesthetic skin rejuvenation. It is the original and most concentrated version in the PLINEST range, delivering both cosmetic and functional benefits for patients seeking visible anti-aging effects with biologically active ingredients.

Key Benefits:

• Improves hydration by +14.7%
• Increases skin elasticity by +21.8%
• Reduces fine lines and wrinkles in over 90% of patients
• 16.7% reduction in skin roughness after 30 days
• Stimulates fibroblast activity and angiogenesis
• Prepares skin for advanced aesthetic procedures
• Visible results after 3 to 4 sessions
• Non-allergenic, biocompatible, and well-tolerated

PLINEST Composition

PLINEST contains long-chain deoxyribonucleotide polymers, purified using a proprietary technology that ensures maximum biocompatibility and zero immunogenic risk. It is delivered in a sterile, non-pyrogenic gel optimized for dermal integration.

Per 2ml Syringe:

• PN-HPT™ (Polynucleotides Highly Purified Technology): 40 mg
• Sterile, viscoelastic, non-pyrogenic carrier gel
• No lidocaine – maximizing suitability for sensitive areas

Needles Supplied: 2 x 30G ½ inch needles per box

PLINEST Intended Purpose / Indications

PLINEST is designed for bio-revitalization and skin regeneration, targeting signs of aging, texture irregularities, and loss of elasticity. It is also suitable for acne scar treatment and aesthetic preparation before other procedures.

Primary Indications:

• Fine wrinkles and skin laxity
• Dehydrated or tired-looking skin
• Dull tone and uneven texture
• Acne scars and fibrotic skin zones
• Skin priming before lasers, fillers, or surgery

PLINEST is recommended for face, neck, and décolleté, as well as for general skin improvement in both young and aging patients.

PLINEST Injection and Treatment Areas

PLINEST is injected intradermally into areas requiring biological rejuvenation, whether for aesthetic enhancement or clinical correction.

Treatment Areas:

• Face (cheeks, forehead, nasolabial area)
• Neck
• Décolleté
• Acne-scarred skin

Injection Depth: Intradermal
Technique: Micro-droplet or linear retrograde
Recommended Volume: 2 ml per session
Needle Size: 30G ½ inch

PLINEST Reconstitution and Preparation Guidelines

PLINEST is provided in a ready-to-use pre-filled syringe. No reconstitution or dilution is needed, simplifying handling for practitioners.

Preparation Instructions:

• Allow syringe to reach room temperature
• Ensure aseptic technique throughout
• Attach included 30G needle
• Expel any air and ensure smooth flow before injecting

PLINEST Administration and Dosage

PLINEST should be administered only by qualified medical professionals, with proper training in intradermal injection techniques.

Standard Protocol:

• 1 session every 14–21 days
• 3 to 4 initial sessions depending on skin condition
• Maintenance: 1 session every 1–3 months

Injection Techniques:

• Micro-droplet: 0.1–0.2 ml per point
• Linear retrograde: For areas with deep laxity or scarring

Results begin to appear after the second session, with visible improvement by the 30-day follow-up.

PLINEST Storage Instructions

To maintain efficacy and product safety, PLINEST must be stored in accordance with medical device guidelines.

Storage Conditions:

• Temperature: 2°C to 25°C
• Avoid exposure to heat and light
• Do not freeze
• Always check batch number and expiry date before use

PLINEST Contraindications

Though safe and biologically compatible, PLINEST should be avoided in certain medical conditions or risk-prone patients.

Contraindicated In:

• Allergy or hypersensitivity to polynucleotides
• Inflamed or infected skin in the treatment area
• Patients with autoimmune diseases
• Pregnant or breastfeeding individuals
• Individuals with coagulation disorders

PLINEST Precautions and Warnings

While PLINEST has an outstanding safety profile, specific precautions are essential to avoid complications and ensure optimal outcomes.

Key Precautions:

• Do not inject into blood vessels
• Use only in sterile clinical settings
• Avoid overcorrection—inject slowly and uniformly
• Monitor for signs of hypersensitivity post-treatment
• Not to be mixed with other injectables in the same syringe

PLINEST Post-Treatment Care

Post-injection care is essential for enhancing treatment benefits and minimizing temporary side effects.

Aftercare Instructions:

• Avoid makeup, UV exposure, and heat treatments for 24–48 hours
• Refrain from massaging or rubbing the treated area
• Use cold compresses to reduce redness or swelling
• Encourage hydration and sun protection

PLINEST Side Effects and Adverse Reactions

PLINEST is generally well-tolerated. Most adverse events are mild and self-limiting.

Common Side Effects:

• Redness or slight swelling
• Bruising or tenderness at injection sites
• Mild itching or tightness

Rare Side Effects:

• Small papules at injection points
• Allergic reactions (extremely rare)
• Localized infection (preventable with aseptic handling)

If any severe symptoms occur, patients should be advised to contact their physician.

PLINEST Patient Eligibility

PLINEST is suitable for a wide demographic of patients, from early-stage aging to those requiring more intensive regenerative support.

Eligibility Criteria:

• Adults aged 18 years and above
• Individuals with early to moderate skin aging
• Patients with acne scars or skin laxity
• Not suitable for pregnant, breastfeeding, or immunocompromised individuals

A detailed consultation and skin assessment are recommended before beginning treatment.

PLINEST Follow-Up and Maintenance

To sustain results, patients should follow a maintenance plan tailored to their age, skin type, and initial condition.

Recommended Follow-Up:

• Initial improvement: 3–4 sessions spaced 2–3 weeks apart
• Long-term maintenance: 1 session every 2–3 months
• Can be combined with fillers, lasers, RF, or peeling treatments

PLINEST Manufacturer and Regulatory Information

PLINEST is produced by Mastelli Srl, a pioneer in regenerative medicine and aesthetics. It adheres to CE medical device standards and is manufactured under ISO 13485:2016 quality control.

Manufacturer Details:

• Company: Mastelli Srl
• Location: Italy
• Medical Classification: CE-certified Class III medical device
• Packaging: 1 x 2ml prefilled syringe, 2 x 30G needles
• Traceability: Batch number and expiry date clearly labeled

PLINEST FAQ

How long until I see results?
Initial improvements are seen after 2–3 sessions, with full results visible by 30 days post-treatment.

Is it painful?
Injections may cause slight discomfort. A topical anesthetic can be applied if needed.

Can it be combined with other treatments?
Yes, PLINEST enhances the effects of lasers, fillers, microneedling, and more.

How long do results last?
Results typically last 3–6 months, with regular maintenance recommended.

Who is it for?
PLINEST is ideal for anyone seeking skin rejuvenation, acne scar repair, or anti-aging support without adding volume.