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PLINEST EYE Product Description

PLINEST EYE is a specialized injectable bio-revitalization product designed for the delicate periocular area. It features PN-HPT™ (Polynucleotides Highly Purified Technology), a proprietary ingredient derived from DNA fragments, specifically formulated at 15mg/2ml concentration to deliver visible improvement in skin texture, elasticity, and hydration without causing edema or excessive tissue pulling.

Developed by Mastelli, PLINEST EYE addresses the common aesthetic concerns around the eyes, such as fine lines, crow’s feet, under-eye hollowness, and eyelid laxity. This low-concentration PN formulation is ideal for the thin, sensitive skin in the eye contour area and has shown clinical efficacy and safety, validated by both physician assessments and 3D skin imaging.

PLINEST EYE Key Features and Benefits

PLINEST EYE delivers dual action: biological skin renewal through polynucleotides and aesthetic correction for the fragile periocular region. It stands out due to its tailored low concentration of PN-HPT™, specifically balanced to stimulate fibroblasts without causing overcorrection or inflammation.

Key Benefits:

• Improves skin quality around the eyes, including elasticity and texture
• Reduces fine wrinkles, crow’s feet, and under-eye lines
• Enhances radiance and smoothness of periocular skin
• Visibly tightens sagging skin, including eyebrow ptosis
• Over 90% of patients observed visible improvements
• Minimal downtime and high safety profile
• Compatible with other aesthetic procedures for synergy

PLINEST EYE Composition

PLINEST EYE contains highly purified DNA polymers that offer bio-regenerative support for delicate skin. The formulation is non-pyrogenic, viscoelastic, and ensures biocompatibility.

Per 2ml Syringe:

• PN-HPT™ (Polynucleotides Highly Purified Technology): 15 mg
• Sterile, non-pyrogenic viscoelastic gel
• No added lidocaine, to reduce the risk of sensitivity in delicate zones

Needle: Supplied with 2 x 30G ½ inch needles, optimized for fine, intradermal injections.

PLINEST EYE Intended Purpose / Indications

PLINEST EYE is developed specifically for periorbital rejuvenation, aiming to regenerate, tighten, and brighten the skin in this high-demand area. It targets a wide range of aesthetic issues commonly seen in aging or fatigued eyes.

Indications Include:

• Fine wrinkles around the eyes (crow’s feet)
• Skin laxity in upper/lower eyelids
• Loss of brightness and radiance
• Tired or sunken eye appearance
• Eyebrow ptosis or sagging
• Pre- and post-aesthetic procedure skin priming

This product is suitable for both younger and aging skin, making it versatile for prevention and correction.

PLINEST EYE Injection and Treatment Areas

PLINEST EYE is formulated for intradermal injection in the eye contour region, ensuring optimal absorption and minimal risk of complications in delicate tissues.

Treatment Areas:

• Under-eye region
• Crow’s feet
• Eyelid margin
• Brow area (for eyebrow lifting)

Technique Options:

• Micro-droplet injections spaced 0.5 to 1 cm apart
• Linear retrograde technique for broader diffusion

Injection Depth: Intradermal
Recommended Volume: 1–2 ml per session

PLINEST EYE Reconstitution and Preparation Guidelines

PLINEST EYE is provided in a ready-to-use prefilled syringe and does not require dilution or reconstitution.

Preparation Steps:

• Allow to reach room temperature before use
• Ensure sterile handling and gloves
• Attach the provided 30G ½ needle
• Prime the syringe and ensure smooth product flow

PLINEST EYE Administration and Dosage

PLINEST EYE should only be administered by trained professionals experienced in treating the periocular region due to its complex anatomy and sensitivity.

Protocol:

• 1 session every 14–21 days
• Total of 3–4 sessions
• Inject 1–2 ml per session depending on area and patient profile

Sessions can be adjusted based on skin response and clinical goals.

PLINEST EYE Storage Instructions

To ensure stability and safety, PLINEST EYE must be stored under specific conditions.

Storage Guidelines:

• Temperature: 2°C to 25°C
• Do not freeze
• Keep in original packaging away from direct sunlight
• Always check the expiry date before use

PLINEST EYE Contraindications

PLINEST EYE should not be used in individuals with specific allergies or active skin conditions, or in situations where the procedure poses a health risk.

Contraindicated In:

• Known hypersensitivity to polynucleotides
• Active infections, inflammation, or skin lesions in the treatment area
• Pregnancy or breastfeeding
• Patients with autoimmune diseases or severe immunosuppression

PLINEST EYE Precautions and Warnings

Though PLINEST EYE is very well-tolerated, caution is needed due to the vascular nature of the eye region and the risk of incorrect placement.

Key Precautions:

• Do not inject into blood vessels
• Avoid aggressive pressure or deep dermal placement
• Use small, slow injections to reduce risk of edema or nodules
• Do not mix with other injectable products in the same syringe

Post-injection monitoring is advised to watch for early signs of complications.

PLINEST EYE Post-Treatment Care

Proper aftercare is crucial to support the rejuvenation process and minimize side effects in this highly sensitive area.

Aftercare Recommendations:

• Avoid makeup, creams, and eye rubbing for 24 hours
• Refrain from saunas, steam rooms, or sun exposure for 48 hours
• Use cold compresses if mild swelling occurs
• Sleep with head elevated on the first night

PLINEST EYE Side Effects and Adverse Reactions

PLINEST EYE has shown a very low incidence of side effects due to its gentle concentration and highly purified formulation.

Expected Side Effects (Mild):

• Redness
• Swelling
• Mild bruising
• Temporary tenderness or itching

Rare Side Effects (Severe):

• Nodules or granulomas
• Infection
• Vascular compromise (rare and requires emergency attention)

Report any prolonged or unexpected symptoms to a healthcare provider immediately.

PLINEST EYE Patient Eligibility

PLINEST EYE is ideal for a wide range of patients, from those wanting to prevent signs of aging to those already experiencing visible periocular laxity or wrinkles.

Eligibility Criteria:

• Adults over 18 years old
• No known hypersensitivities to PN or injection materials
• Not pregnant or breastfeeding
• No active dermatologic or systemic disease affecting the eyes

PLINEST EYE Follow-Up and Maintenance

To maintain and enhance results, follow-up sessions and maintenance treatments are advised based on skin condition and age.

Recommended Maintenance:

• Initial protocol: 3–4 sessions spaced 2–3 weeks apart
• Maintenance: 1 session every 3–4 months
• Synergistic use with laser, microneedling, fillers, or peeling is encouraged

PLINEST EYE Manufacturer and Regulatory Information

PLINEST EYE is developed by Mastelli Srl, a pioneer in regenerative medical devices. It adheres to the highest international quality standards.

Manufacturer Details:

• Company: Mastelli Srl
• Country: Italy
• Medical Classification: CE-certified medical device
• Packaging: 1 x 2ml pre-filled syringe with 2 x 30G ½ needles
• Batch Code and expiry clearly indicated on each unit

PLINEST EYE FAQ

How soon will I see results?
Typically within 2–4 weeks, with continued improvement through the treatment cycle.

Is it painful?
Discomfort is minimal, but due to the delicate area, some sensitivity may occur. Topical anesthetic can be used.

Can I wear makeup after treatment?
Wait at least 24 hours before applying makeup to reduce infection risk.

Can PLINEST EYE be combined with other treatments?
Yes, it is an excellent priming product and enhances results when used alongside other aesthetic procedures.

How long do results last?
Results can last 6–8 months, with 3–4 month maintenance sessions recommended for sustained outcomes.