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PLINEST HAIR Product Description

PLINEST HAIR is a sterile injectable gel developed for bio-revitalization of the scalp and eyebrows, using PN-HPT™ (Polynucleotides Highly Purified Technology). Created by Mastelli, a leader in regenerative medical aesthetics, this formulation is clinically proven to stimulate hair follicle activity, improve scalp condition, and reduce hair loss, particularly in cases of female hormonal alopecia.

Containing 15mg of PN-HPT™ in a 2ml sterile gel, PLINEST HAIR targets both the biological triggers of hair loss and the structural health of scalp tissue. It is ideal for standalone hair revitalization or as a complementary treatment alongside biotin, PRP, or other hair restoration therapies.

PLINEST HAIR Key Features and Benefits

PLINEST HAIR offers a non-hormonal, non-surgical solution for patients experiencing thinning hair, scalp weakness, or eyebrow loss. It restores the scalp microenvironment, promotes angiogenesis, and supports hair growth in the anagen phase.

Key Benefits:

• Stimulates fibroblast activity and collagen synthesis in the scalp
• Improves hair density and hair shaft strength
• Reverses telogen (resting phase) dominance
• Safe for use in female hormonal hair loss without systemic side effects
• Enhances results when combined with mesotherapy, microneedling, or biotin therapy
• No downtime, minimally invasive, and well-tolerated

Clinical studies report over 72% of patients experienced an objective improvement in hair density and scalp condition.

PLINEST HAIR Composition

PLINEST HAIR contains highly purified DNA fractions formulated into a viscoelastic gel optimized for intradermal scalp injection.

Per 2ml Syringe:

• PN-HPT™ (Polynucleotides Highly Purified Technology): 15 mg
• Sterile, non-pyrogenic, viscoelastic carrier gel
• No added lidocaine, ensuring safe application to sensitive scalp areas

The PN-HPT™ complex not only supports wound healing and anti-inflammatory activity, but also acts as a biological signal for dermal rejuvenation and vascular stimulation.

PLINEST HAIR Intended Purpose / Indications

PLINEST HAIR is intended for biological stimulation of hair follicles and scalp regeneration in both men and women, with particular efficacy in female hormonal alopecia.

Primary Indications:

• Female hormonal alopecia (non-androgenic)
• General scalp thinning or loss of density
• Eyebrow thinning or patchiness
• Hair cycle irregularities (low anagen-to-telogen ratio)
• Prevention of hair loss in at-risk patients

It is suitable for use alone or in combined protocols for enhanced therapeutic impact.

PLINEST HAIR Injection and Treatment Areas

The product is designed for intradermal injection into the scalp or eyebrow area, delivering localized regenerative effects.

Treatment Areas:

• Scalp (frontal, temporal, parietal, and occipital regions)
• Eyebrows

Injection Depth: Intradermal
Technique: Micro-droplet or linear retrograde
Needle Size: 30G ½ inch
Recommended Volume: 2 ml per session

PLINEST HAIR Reconstitution and Preparation Guidelines

PLINEST HAIR is supplied in a ready-to-use prefilled syringe. No dilution or reconstitution is necessary.

Preparation Steps:

• Allow to reach room temperature before use
• Use aseptic technique throughout preparation and injection
• Attach the provided 30G needle
• Expel any air and ensure a smooth flow of product

PLINEST HAIR Administration and Dosage

PLINEST HAIR is administered in two structured phases: intensive stimulation followed by maintenance. A full cycle spans approximately 2–3 months.

Dosage and Protocol:

• Phase I (Stimulation):
  4 sessions, spaced every 7–14 days
• Phase II (Maintenance):
  4 sessions, spaced every 21–30 days

Injection Techniques:

• Micro-droplet technique at intervals of 0.5–1 cm
• Linear retrograde technique for broader diffusion

Each session typically requires the full 2 ml syringe.

PLINEST HAIR Storage Instructions

To maintain product efficacy and sterility, PLINEST HAIR must be stored under controlled environmental conditions.

Storage Guidelines:

• Store between 2°C and 25°C
• Do not freeze
• Protect from direct sunlight
• Use prior to the expiry date indicated on packaging

PLINEST HAIR Contraindications

Despite its excellent safety profile, PLINEST HAIR should not be used in patients with certain health conditions or sensitivities.

Contraindications:

• Known allergy to polynucleotides
• Presence of active scalp infections, dermatitis, or inflammation
• Autoimmune diseases or patients undergoing immunosuppressive therapy
• Pregnancy and breastfeeding
• Recent scalp trauma or surgery (without physician clearance)

PLINEST HAIR Precautions and Warnings

Although well-tolerated, care must be taken to avoid incorrect injection depth or contamination during administration.

Key Precautions:

• Inject only into the intradermal layer, avoiding deeper subcutaneous planes
• Avoid treating areas with compromised skin integrity
• Do not mix with other substances in the same syringe
• Use new sterile needle for each patient and session
• Monitor patient’s skin response during the first 24 hours

PLINEST HAIR Post-Treatment Care

To maximize treatment benefits and reduce side effects, proper aftercare should be followed.

Post-Treatment Instructions:

• Avoid washing the scalp for at least 6 hours
• Refrain from applying hair products, dyes, or heat styling for 48 hours
• Avoid excessive sun exposure, saunas, or steam rooms for 2 days
• Inform patients to avoid scratching or disturbing the injection sites

PLINEST HAIR Side Effects and Adverse Reactions

PLINEST HAIR is associated with minimal side effects, primarily due to its biocompatibility and non-cytotoxic formulation.

Common Side Effects:

• Mild redness or itching at injection site
• Transient swelling or soreness
• Minor bruising

Rare but Possible Reactions:

• Small nodules at injection sites
• Infection (if asepsis is compromised)
• Allergic or inflammatory reaction (extremely rare)

Any severe or unexpected side effects should be reported immediately.

PLINEST HAIR Patient Eligibility

PLINEST HAIR is ideal for adult patients looking to combat thinning hair, improve scalp vitality, or support eyebrow density.

Eligible Patients:

• Adults (18+) experiencing hair thinning or early-stage alopecia
• Women with hormonal-related hair loss
• Patients seeking non-invasive hair restoration
• Those with no contraindications or known sensitivities to PN

PLINEST HAIR Follow-Up and Maintenance

Long-term benefits from PLINEST HAIR are best achieved through structured treatment plans and routine maintenance.

Suggested Protocol:

• Full treatment: 8 sessions over 2–3 months
• Maintenance: 1 session every 2–3 months, or as needed
• Combine with PRP, biotin, or microneedling for amplified results

PLINEST HAIR Manufacturer and Regulatory Information

PLINEST HAIR is developed and produced by Mastelli Srl, renowned for its innovations in aesthetic regenerative medicine.

Manufacturer Details:

• Company: Mastelli Srl
• Country: Italy
• Classification: CE-certified medical device
• Packaging: 1 x 2ml prefilled syringe with 2 x sterile 30G needles
• Regulatory Compliance: Conforms to EU Medical Device Regulation
• Traceability: Batch number and expiry date labeled on each unit

PLINEST HAIR FAQ

How long until I see results?
Most patients observe visible improvement in hair texture and volume within 6–8 weeks.

Is it painful?
Discomfort is minimal; a fine 30G needle is used. Topical numbing is optional.

Is it safe for men and women?
Yes. Though studied more extensively in women with hormonal alopecia, it is safe for both genders.

Can it be combined with PRP or biotin therapy?
Yes, it works well in synergy with other hair restoration treatments.

Will it stop my hair loss permanently?
PLINEST HAIR stimulates regrowth and improves hair quality but does not alter the underlying cause of genetic or hormonal alopecia. Ongoing maintenance may be required.