According to the Centers for Disease Control and Prevention (CDC), nearly 14 million adults in the United States are affected by knee osteoarthritis. This degenerative joint disease causes pain, stiffness, and limited mobility, significantly impacting quality of life. As the prevalence of knee osteoarthritis continues to grow, the need for effective treatment options becomes even more essential.

Two leading injectable treatments—Supartz and Euflexxa—have emerged to address this demand. These hyaluronic acid injections lubricate the knee joint, helping relieve pain and improve joint function. Understanding their differences and similarities is key to helping patients and healthcare providers choose the most suitable treatment.

In this article, we’ll compare Supartz vs Euflexxa, exploring their mechanisms, benefits, potential side effects, and effectiveness in managing knee osteoarthritis.

Key Takeaways

  • Supartz and Euflexxa are two leading hyaluronic acid-based treatments designed to relieve knee pain, enhance joint lubrication, and improve function. Both can help delay or reduce the need for knee replacement surgery.
  • Supartz provides long-term pain relief with a five-injection regimen, often recommended for sustained management of osteoarthritis. However, it requires a multi-week treatment schedule, which may not be ideal for those seeking quicker relief.
  • Euflexxa requires only three injections for faster relief, which can appeal to patients looking for a shorter treatment protocol. However, higher initial costs may be a consideration for some patients.
  • Deciding between Supartz and Euflexxa should involve a discussion with a healthcare professional, considering individual needs, treatment goals, and lifestyle preferences.

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Understanding Osteoarthritis and Viscosupplements

Osteoarthritis (OA) is a common joint condition in which the cartilage that cushions the joints breaks down over time, leading to pain, stiffness, and reduced mobility. In the knee, this can make simple activities like walking difficult.

doctor checking the knee

Viscosupplements are a treatment option for knee OA. These injections introduce hyaluronic acid, a natural substance that helps restore lubrication and cushioning in the joint. By improving the joint’s fluid balance, viscosupplements work to reduce pain, increase mobility, and make it easier for patients to manage their OA symptoms.

Supartz

Supartz is a treatment for knee pain caused by osteoarthritis. Made from purified sodium hyaluronate derived from chicken combs, it closely mimics the body’s natural joint fluid to improve lubrication and cushioning in the knee joint.

In the body, Supartz acts as a lubricant and shock absorber, helping to ease discomfort and enhance knee function, especially when other treatments haven’t provided relief. By replenishing hyaluronic acid in the knee, Supartz restores smooth joint movement and reduces the pain associated with osteoarthritis.

Euflexxa

Euflexxa is a hyaluronic acid treatment designed to relieve knee pain in patients with osteoarthritis by closely mimicking the body’s natural joint fluid. Composed of highly purified, partially cross-linked sodium hyaluronate, it provides effective lubrication and cushioning in the knee joint to reduce pain and improve mobility.

Euflexxa’s unique formulation allows it to last longer in the joint, offering patients quicker relief with fewer injections. Typically administered as a series of three injections, Euflexxa helps restore smooth movement and knee function, making it a reliable option for those seeking relief when other treatments are ineffective.

Effectiveness of Supartz and Euflexxa

Supartz (sodium hyaluronate) has demonstrated efficacy in treating knee osteoarthritis. Clinical trials have indicated significant pain reduction and improved function lasting up to six months. Patients experience meaningful relief from a single 5-week course using Supartz.

  • Mol..: “This is my second year of using Supartz. So far, it is working. I refused to get a knee replacement and looked for other options, and this came up…The weight loss was beneficial. Just 25 lbs, but it made a difference.”

Viscosupplementation, including Supartz, effectively reduces knee pain, enhances functionality, and delays the need for surgery in osteoarthritis patients. Systematic reviews highlight the benefits and emerging evidence supporting such treatments, emphasizing their role in managing chronic knee pain and improving patients’ quality of life.

Meanwhile, a 12-week double-blind trial comparing Euflexxa to Synvisc involved 321 patients with stage 2-3 knee osteoarthritis who experienced significant pain relief, measured by the WOMAC pain scores. 

  • Siw..: “After years of increasing pain, I finally decided to try Euflexxa. Why did I wait so long? After the first injection, I had NO pain, no swelling, and no adverse reactions of any kind. I’ve just completed my third injection, and still no pain. I now know what it is like to walk without pain. Relief!”

Euflexxa demonstrated statistically significant and clinically meaningful improvements in pain relief. In a 26-week randomized, placebo-controlled study involving 588 patients with knee osteoarthritis, Euflexxa showed superior pain reduction compared to saline. 

Advantages and Disadvantages of Supartz

Supartz injections are effective at reducing pain and enhancing mobility for those battling osteoarthritis. While this treatment may have benefits, patients should be aware of its drawbacks before deciding on it.

patient receiving knee injection

Benefits of Supartz

  • Offers long-term pain relief for osteoarthritis
  • Delays or reduces the need for knee replacement surgery
  • Improves knee mobility and overall joint function

Drawbacks

  • Requires a commitment to five injections over five weeks
  • The full treatment schedule may be challenging for some patients
  • Results vary depending on individual responses

While Supartz can provide significant, lasting benefits, its multi-week treatment schedule may not be ideal for those seeking faster relief. Supartz side effects are generally mild, including pain, swelling, or discomfort at the injection site. Always consult with your doctor to determine if Supartz is the most suitable option for managing your knee osteoarthritis symptoms and to discuss any concerns about side effects.

Advantages and Disadvantages of Euflexxa

Like Supartz, Euflexxa treatments have their fair share of advantages and disadvantages. Patients need to know about this beforehand to decide if this treatment will match their needs for pain relief.

Benefits

  • Faster relief with only three injections required
  • May reduce the need for knee replacement surgery
  • More cost-effective for patients who prefer fewer injections

Drawbacks

  • Patients seeking a more gradual treatment may prefer other options
  • Initial cost may be higher compared to other treatments
  • Potential side effects include pain, swelling, and headaches

Euflexxa’s shorter treatment schedule can be highly appealing to those looking for quick results. However, factors like cost and treatment preferences are important to consider when choosing the right option for knee osteoarthritis.

Choosing the Best Option for Osteoarthritis Management

Both Euflexxa and Supartz are effective options for managing knee pain caused by osteoarthritis, each with unique advantages. Euflexxa may provide quicker relief with only three injections, while Supartz requires five injections, potentially offering more long-term benefits. Choosing between these treatments involves several key considerations, such as:

consultation for patient with painful knee joint
  • Treatment Time: Euflexxa’s three-shot regimen is shorter than Supartz’s five-shot schedule.
  • Cost: Fewer injections with Euflexxa may make it more affordable for some patients.
  • Patient Comfort: Patients seeking faster relief may prefer Euflexxa’s shorter timeline.
  • Long-term Care: Supartz is often recommended for sustained pain management.
  • Side Effects: Both treatments have potential side effects that should be discussed.
  • Effectiveness: Studies show both reduce pain, improve function, and may help delay knee replacement surgery.
  • Convenience: Fewer injections, as with Euflexxa, mean fewer healthcare visits, which can ease the burden on patients and the healthcare system.

Conclusion

Choosing between Supartz and Euflexxa depends on your individual needs and treatment goals. Euflexxa may offer faster relief with a shorter injection schedule, while Supartz could be more suitable for those seeking sustained, long-term care. Both treatments are effective in managing knee pain from osteoarthritis.

Consulting with your doctor is essential to determine the best option for your specific needs and preferences, ensuring you receive the most effective relief and support.

FAQs

1. What is Supartz used for?

Supartz treats knee osteoarthritis by lubricating the joint, reducing pain, and improving mobility.

2. How does Supartz work?

Supartz contains hyaluronic acid, which helps lubricate the knee joint, reduce pain, and improve movement in people with osteoarthritis.

3. How is Supartz administered?

Supartz is administered directly into the knee joint as an injection. A typical treatment involves a series of 3 to 5 injections, usually given once a week for several weeks. 

4. Are there any side effects of Supartz?

Common side effects include pain, swelling, or redness at the injection site. Serious side effects are rare.

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References

Centers for Disease Control and Prevention. Osteoarthritis. Published June 10, 2024. https://www.cdc.gov/arthritis/osteoarthritis/index.html 

Pereira TV, Jüni P, Saadat P, et al. Viscosupplementation for knee osteoarthritis: systematic review and meta-analysis. BMJ. Published online July 6, 2022:e069722. doi:https://doi.org/10.1136/bmj-2022-069722