Viscosupplements, such as hyaluronic acid injections, have become a popular treatment for osteoarthritis (OA). They offer significant pain relief and improved joint function. A comprehensive review found that viscosupplementation is more effective than NSAIDs and corticosteroids in reducing pain and enhancing mobility.
Two leading viscosupplements for knee OA are Synvisc and Euflexxa. Both treatments work by restoring the lubrication in the knee joint, reducing friction, and helping patients regain mobility. However, there are key differences in their composition, administration, and long-term effectiveness.
In this article, we will compare Synvisc vs Euflexxa, highlighting their benefits, side effects, and what patients can expect from each treatment.
Key Takeaways
- Both Synvisc and Euflexxa are hyaluronic acid-based injections used to treat knee osteoarthritis. They help reduce pain and improve mobility.
- Synvisc contains hyaluronan derived from rooster combs. Patients can opt for a single-dose (Synvisc-One) or a three-injection regimen, which provides up to six months of pain relief.
- Euflexxa is bioengineered through bacterial fermentation, requiring three injections to provide up to six months of relief.
- Patient preference varies: Synvisc offers a convenient single shot (Synvisc One), while Euflexxa patients appreciate the long-term mobility improvements despite the three-dose schedule.
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Understanding Osteoarthritis and Viscosupplements
Osteoarthritis (OA) is a degenerative joint disease affecting millions worldwide, especially in the knees. It occurs when the cartilage that cushions the ends of bones breaks down over time, leading to pain, stiffness, and reduced mobility. As the condition worsens, daily activities such as walking, climbing stairs, or even sitting can become difficult and painful.
Viscosupplements are injectable treatments used to manage knee osteoarthritis symptoms. They contain hyaluronic acid, a substance that mimics the natural synovial fluid found in healthy joints. This fluid provides lubrication and cushioning, reducing friction between the bones.
By injecting viscosupplements directly into the affected joint, the goal is to restore the natural viscosity and elasticity of the joint fluid. This can help reduce pain, improve mobility, and delay the need for more invasive treatments like surgery.
Synvisc
Synvisc is a popular viscosupplement used to treat knee osteoarthritis. This hyaluronic acid-based injection mimics the natural fluid in the joint, providing lubrication and cushioning to reduce pain and improve mobility. By restoring joint fluid, Synvisc helps ease discomfort, making it easier for patients to perform everyday activities.
Synvisc knee injections can be administered in either a single-dose treatment (Synvisc-One) or a three-injection regimen, depending on the severity of the osteoarthritis and the patient’s specific needs. This flexibility allows doctors to tailor the treatment to individual cases, providing optimal relief.
Patients report high satisfaction with Synvisc due to its ability to delay the need for knee surgery and provide up to six months of pain relief. However, it’s important to be aware of potential Synvisc side effects, which can include temporary swelling, joint stiffness, or pain at the injection site.
Euflexxa
Euflexxa is an injectable treatment designed to relieve knee pain caused by osteoarthritis. It works by replenishing the hyaluronic acid in the joint, restoring the natural cushion between the bones, which reduces friction, swelling, and discomfort. The complete treatment involves three injections administered over several weeks.
In terms of patient satisfaction, Euflexxa has been well-received. Many patients find that it helps delay the need for knee surgery while allowing them to enjoy daily activities with less pain. Despite the three-injection regimen, patients often feel the benefits outweigh the commitment, experiencing noticeable improvement in mobility and quality of life.
Comparing Synvisc and Euflexxa
When choosing between Synvisc vs Euflexxa for knee osteoarthritis treatment, it’s important to understand how these two viscosupplements differ. While both are designed to alleviate joint pain and improve mobility, their formulations, treatment processes, and overall patient experiences vary.
Below, we’ll compare Synvisc and Euflexxa across several key areas:
| Synvisc | Euflexxa | |
| Formulation | Hyaluronan derived from rooster combs | Bioengineered from bacterial fermentation |
| Injection Schedule | 1 (Synvisc One) or three injections | Three injections |
| Duration of Relief | Up to 6 months | Up to 6 months |
| Patient Satisfaction and Preference | Patients appreciate the convenient one-shot option. Many report high satisfaction due to the ease and effectiveness of this treatment | Patients note effective pain relief and improved mobility but requires 3 shots |
Both Synvisc and Euflexxa are effective in reducing pain and improving joint function in patients with osteoarthritis. Studies have shown that both treatments can relieve pain and improve mobility. However, some research suggests that Euflexxa may have a slight edge in terms of reducing the number of joint effusions and the need for supplemental analgesics.
Ultimately, the choice between them may depend on individual patient needs, preferences, and specific medical advice from healthcare providers.
Conclusion
Choosing between Synvisc vs Euflexxa for knee osteoarthritis depends on several factors, including cost, the frequency of injections, and insurance coverage. Both treatments are effective in providing relief from pain and improving mobility.
Consult your doctor to determine which option is best suited to your needs. Each treatment offers unique benefits, helping you regain comfort and ease in daily activities with less pain and stiffness.
FAQs
1. How do Synvisc and Euflexxa differ in composition?
Synvisc is made from hyaluronan derived from rooster combs, while Euflexxa is a non-avian, bioengineered hyaluronic acid.
2. How long does relief last with each treatment?
Both Synvisc and Euflexxa provide pain relief for up to six months after treatment.
3. What’s the difference in the injection schedule?
Synvisc offers patients the option of a one—or three-injection regimen, while Euflexxa’s standard schedule involves three injections spaced one week apart.
4. Are there any side effects of Synvisc and Euflexxa?
Common side effects include pain and swelling at the injection site. Rare but serious side effects, such as joint infections or allergic reactions, should be reported to a doctor immediately.
References
Peck J, Slovek A, Miro P, et al. A comprehensive review of viscosupplementation in osteoarthritis of the knee. Orthopedic Reviews. 2021;13(2). doi:10.52965/001c.25549
Pereira, T. V., Jüni, P., Saadat, P., Xing, D., Yao, L., Bobos, P., et al. (2022). Viscosupplementation for knee osteoarthritis: Systematic review and meta-analysis. BMJ, 378, e069722. https://doi.org/10.1136/bmj-2022-069722
Drugs.com. (n.d.). Synvisc-One side effects. Drugs.com. Retrieved from https://www.drugs.com/sfx/synvisc-one-side-effects.html
