HYMOVIS®

What is Hymovis?

Hymovis® is a next-generation orthopaedics product developed by Fidia Pharma USA (a subsidiary of Fidia Farmaceutici, Italy) that delivers a high-viscosity hyaluronic acid hydrogel into the knee joint to manage pain and improve mobility in knee osteoarthritis patients. Engineered to closely mimic the biomechanical properties of healthy synovial fluid, this injectable solution lubricates articular surfaces, cushions mechanical stress, and reduces friction, protecting against further joint degradation. Its unique Hymovis hydrogel formulation, known as HYADD®4, achieves these benefits without chemical cross-linking, promoting longer-lasting joint support with just two injections, one week apart.

Clinical trials have demonstrated significant pain relief and functional improvement in patients with knee osteoarthritis, often comparable to more extended regimens with other viscosupplements. In one controlled study, two weekly Hymovis injections produced non-inferior efficacy to five-week Hyalgan treatments, as evaluated by WOMAC pain scores over six months.

Additional follow-up studies confirmed the maintenance of improvement in pain, stiffness, and joint function up to a year after treatment. Reported side effects were mild and transient, most commonly joint soreness or swelling at the injection site.

What ingredients are Hymovis brand products made up of?

Hymovis® features HYADD®4, a chemically unaltered hyaluronic acid derivative produced via bacterial fermentation. Packaged in 3 mL syringes, each single-dose product delivers 24 mg of HYADD®4 in an isotonic, buffered solution, specifically formulated to mimic and enhance the natural lubrication in the knee joint affected by knee osteoarthritis.

This HYADD®4 injectable solution uses long-chain hyaluronic acid that resists rapid breakdown, offering enhanced shock absorption and joint lubrication without chemical cross-linking. It includes carefully measured excipients—sodium chloride and phosphate buffers —to maintain osmotic balance and ensure patient comfort during administration using aseptic technique.

What can the Hymovis product treat?

Hymovis® serves as a clinically proven treatment for relieving pain associated with symptomatic knee osteoarthritis in patients who have not found adequate relief from conservative therapies or simple medications like acetaminophen. This injectable product features HYADD®4 — a modified high-viscosity hyaluronic acid hydrogel that mimics the natural synovial fluid found in a healthy knee joint.

By restoring lubrication and shock absorption, Hymovis® helps cushion joint surfaces, reduce friction, and protect damaged cartilage.

Clinically, Hymovis® is administered via two injections (3 mL per session), one week apart, using pre-filled Hymovis syringes. This simple regimen has earned FDA approval for symptomatic relief in osteoarthritis knee patients. The treatment delivers sustained improvements in pain, stiffness, and mobility, often extending up to six months after the injection series.

Hymovis® integrates seamlessly into patient care, providing an efficient, non-surgical option for managing knee OA and enhancing patient outcomes.

What is the duration of the effects of these orthopedic injections?

Hymovis® is an advanced viscosupplement for osteoarthritis knee that offers substantial pain relief and improved care for patients using just two injections, one week apart . Clinical data indicates that many patients experience relief lasting up to six months, aligning with the treatment’s objective to restore joint health through simplified, effective therapy.

• Two-injection regimen: A streamlined protocol—just two weekly injections—endears Hymovis® to both clinicians and patients for its convenience and efficacy.
• Sustained symptom management: Patients report meaningful reductions in pain, stiffness, and improved joint function that last for months. In one study, Hymovis® reduced WOMAC/VAS pain scores by approximately 34% at six months, with further gains observed in real-world clinical use.

Enhanced mobility and quality of life: Up to 86–88% of treated patients met the OMERACT‑OARSI response criteria, signifying significant functional improvement, up to one year post-treatment.

Are these products safe to use?

Hymovis®—an advanced hyaluronic acid solution for osteoarthritis knee pain—offers a favorable safety profile due to its hypoallergenic and minimally invasive nature. Formulated without chemical cross-linking and derived from bacterial hyaluronic acid, this injectable reduces the risk of immune reactions and provides gentle joint support. However, proper care and patient selection are essential.

Based on official Hymovis treatment guidelines, safety measures include:

• Contraindications: Do not use for patients with known hypersensitivity to hyaluronate preparations or gram-positive bacterial proteins, or in cases of infection or skin disease at the treatment area or joint.
• Population limits: Safety has not been established for pregnant women, nursing mothers, or patients under 18 years of age.

When administered by trained medical professionals under aseptic conditions—using prefilled Hymovis syringes—the treatment is well tolerated. The most common events are transient arthralgia, mild swelling, or redness at the site, which typically resolve quickly. No severe adverse reactions like pseudosepsis have been reported in clinical trials or real-world use.

Patient Care and Precautions

Medical professionals should explain the importance of adherence to the post-treatment care to patients. This can help minimize potential risks and optimize treatment outcomes. Other aftercare and treatment protocol precautions include:

• Ensure joint effusion is removed prior to injection.
• Use strict aseptic technique and avoid certain disinfectants (e.g., quaternary ammonium salts) to prevent hyaluronan precipitation.
• Advise patients to avoid strenuous activity for 48 hours post-injection

Information about Hymovis treatment is not comprehensive and does not include all relevant safety and contraindication information. For more details, refer to the Hymovis package insert.

Side Effects

Most patients generally well tolerate Hymovis, but like all orthopaedic products, it may cause side effects in some individuals. These reactions are typically mild to moderate and often resolve without the need for additional treatment.

The most common side effects are related to the injection site and the joint itself, occurring shortly after administration. While Hymovis treatment does not typically lead to systemic complications, patients should still be monitored to ensure optimal care and recovery.

Reported side effects associated with Hymovis may include:

• Knee arthralgia (joint pain)
• Edema or swelling around the injection site
• Transient discomfort in the knee joint

Healthcare professionals should inform patients of these possibilities prior to administration and provide appropriate care if symptoms persist. As a product designed to improve joint health in individuals with osteoarthritis, Hymovis should only be administered by trained professionals under sterile conditions and not used in conjunction with active surgical intervention or skin infections.

We’ve made a dedicated article about Hymovis Side Effects.

Hymovis Therapy Recovery Time

Hymovis therapy offers a minimally invasive approach to managing osteoarthritis-related knee pain, and it typically involves little to no downtime. After receiving a Hymovis injection, most patients can return to their normal daily activities almost immediately.

However, to ensure optimal results and reduce the risk of post-injection discomfort, healthcare providers may recommend limited joint stress for 48 hours following the procedure. This means avoiding high-impact activities such as running, jumping, or prolonged standing.

Is it Safe to Buy Hymovis Online

Yes, it is safe to buy Hymovis online—as long as you source it from a verified and reputable distributor that specializes in medical supplies and surgical products. Hymovis is a specialized viscosupplementation injection approved for intra-articular treatment of knee osteoarthritis. Because it is considered a medical equipment product used under clinical guidance, it should only be ordered through licensed vendors that verify the purchaser’s medical credentials.

Medical professionals looking to order Hymovis should always confirm that the supplier adheres to regulatory standards and distributes authentic hymovis injections manufactured by Fidia Pharma USA.

To ensure safety, healthcare providers must:

• Verify the legitimacy of the shop or platform.
• Confirm that the supplier follows correct storage and shipping protocols.
• Review the vendor’s licensing for distributing medical and surgical products.
• Ensure that Hymovis comes with a proper package insert and batch information.

Ordering through a credible platform also ensures that the product is stored in appropriate temperature-controlled environments, maintaining its clinical integrity until delivery.

Shop Hymovis or other Viscosupplements (Synvisc) At Medical Spa RX

Medical professionals can shop Hymovis and comparable viscosupplements such as Synvisc at Medical Spa RX, a trusted distributor of FDA-approved medical equipment and medical supplies. Medical Spa RX offers licensed buyers access to authentic orthopedic products designed for the management of osteoarthritis-related pain. The platform provides secure ordering, transparent shipping processes, and knowledgeable customer support for clinics and providers across the U.S.

One of the key benefits of ordering from Medical Spa RX is its tier pricing system, which allows clinics and healthcare institutions to buy Hymovis wholesale at a reduced cost per unit. This system offers:

• Discounts for bulk orders of 5, 10, or more units.
• Simplified reorder options for returning clients.
• No minimum quantity requirements to get started.
• Access to a comprehensive range of surgical and medical products.

Healthcare providers seeking to streamline their procurement process can order Hymovis confidently through Medical Spa RX, where quality, authenticity, and professional service are guaranteed.